PMID- 11944905
OWN - NLM
STAT- MEDLINE
DCOM- 20020513
LR  - 20131121
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 292
IP  - 4
DP  - 2002 Apr 12
TI  - Differential effects of histone deacetylase inhibitors on interleukin-18 gene 
      expression in myeloid cells.
PG  - 937-43
AB  - Histone deacetyrase (HDAC) inhibitors induce growth arrest and differentiation of 
      leukemia cell lines and tumor cells derived from a large variety of human 
      tissues. Here we showed that HDAC inhibitors sodium butyrate, TSA, and valproate 
      regulated the expression of Interleukin-18 (IL-18), a cytokine with antitumor and 
      proinflammatory properties, in human acute myeloid leukemia cell lines U937 and 
      HEL. Sodium butyrate increased expression of IL-18 protein and mRNA and activated 
      1357bp IL-18 gene promoter construct. IL-18 mRNA level was up-regulated by TSA or 
      valproate, which also activated IL-18 full-length promoter. While sodium butyrate 
      or TSA stimulated the 108-bp IL-18 minimal promoter, valproate failed to activate 
      it, indicating that valproate may use a distinct mechanism from sodium butyrate 
      and TSA to activate IL-18 gene expression.
CI  - (c)2002 Elsevier Science (USA).
FAU - Koyama, Noriko
AU  - Koyama N
AD  - Department of Hematology, Johann Wolfgang Goethe University, Frankfurt, 60590, 
      Germany. Koyama@em.uni-frankfurt.de
FAU - Koschmieder, Steffen
AU  - Koschmieder S
FAU - Tyagi, Sandhya
AU  - Tyagi S
FAU - Nurnberger, Heike
AU  - Nurnberger H
FAU - Wagner, Sandra
AU  - Wagner S
FAU - Bocker, U
AU  - Bocker U
FAU - Hoelzer, Dieter
AU  - Hoelzer D
FAU - Gerhard Ottmann, Oliver
AU  - Gerhard Ottmann O
FAU - Kalina, Uwe
AU  - Kalina U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Butyrates)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Growth Inhibitors)
RN  - 0 (Histone Deacetylase Inhibitors)
RN  - 0 (Hydroxamic Acids)
RN  - 0 (Interleukin-18)
RN  - 0 (RNA, Messenger)
RN  - 3X2S926L3Z (trichostatin A)
RN  - 614OI1Z5WI (Valproic Acid)
SB  - IM
MH  - Blotting, Northern
MH  - Blotting, Western
MH  - Butyrates/pharmacology
MH  - Cell Differentiation/drug effects
MH  - Cell Division/drug effects
MH  - Cell Line
MH  - Cell Survival/drug effects
MH  - Enzyme Inhibitors/*pharmacology
MH  - Gene Expression/*drug effects
MH  - Growth Inhibitors/pharmacology
MH  - *Histone Deacetylase Inhibitors
MH  - Humans
MH  - Hydroxamic Acids/pharmacology
MH  - Interleukin-18/genetics/*metabolism
MH  - Leukemia, Erythroblastic, Acute/drug therapy/metabolism
MH  - Myeloid Cells/cytology/*drug effects/metabolism
MH  - Promoter Regions, Genetic/drug effects
MH  - RNA, Messenger/metabolism
MH  - U937 Cells
MH  - Valproic Acid/pharmacology
EDAT- 2002/04/12 10:00
MHDA- 2002/05/15 10:01
CRDT- 2002/04/12 10:00
PHST- 2002/04/12 10:00 [pubmed]
PHST- 2002/05/15 10:01 [medline]
PHST- 2002/04/12 10:00 [entrez]
AID - S0006291X02967537 [pii]
AID - 10.1006/bbrc.2002.6753 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2002 Apr 12;292(4):937-43. doi: 
      10.1006/bbrc.2002.6753.