PMID- 11948632
OWN - NLM
STAT- MEDLINE
DCOM- 20020610
LR  - 20220408
IS  - 0270-3211 (Print)
IS  - 0270-3211 (Linking)
VI  - 22
IP  - 3
DP  - 2002
TI  - Evaluation of relationship between chromosome 22 and p53 gene alterations and the 
      subtype of meningiomas by the interphase-FISH technique.
PG  - 217-25
AB  - In this study, we investigated the relationship between genetic alterations such 
      as chromosome 22 aneuploidy and p53 gene deletion, and the pathological types of 
      meningioma of typical and aggressive forms. Thirty-four meningiomas (23 typical 
      and 11 aggressive) were examined by application of fluorescence in situ 
      hybridization (FISH) with chromosome 22 specific alpha satellite probe and a 
      combination of p53 locus specific and chromosome 17 centromere specific alpha 
      satellite probes, to evaluate the chromosome 22 aneuploidy and gain or loss of 
      p53 gene along with chromosome 17. The results showed that, although chromosome 
      22 aneuploidy was seen in 7 out of 23 typical (30.4%) and 4 out of 11 aggressive 
      meningiomas (36.3%), no p53 deletion was detected in typical meningiomas, and p53 
      deletion was detected in 3 out of 11 aggressive meningiomas (1 atypical and 2 
      malignant), which had recurrence. There were no simultaneous occurrences of p53 
      gene deletions between typical and aggressive meningiomas. The present findings 
      indicate that the loss of chromosome 22 may be involved with tumorogenesis of 
      typical and aggressive meningiomas, while p53 gene deletions may be involved with 
      malignant progression and recurrence in the aggressive meningiomas.
CI  - Copyright 2002 Wiley-Liss, Inc.
FAU - Yakut, Tahsin
AU  - Yakut T
AD  - Department of Medical Biology and Genetics, Faculty of Medicine, University of 
      Uludag, Bursa, Turkey.
FAU - Bekar, Ahmet
AU  - Bekar A
FAU - Doygun, Muammer
AU  - Doygun M
FAU - Acar, Hasan
AU  - Acar H
FAU - Egeli, Unal
AU  - Egeli U
FAU - Ogul, Erhan
AU  - Ogul E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Teratog Carcinog Mutagen
JT  - Teratogenesis, carcinogenesis, and mutagenesis
JID - 8100917
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aneuploidy
MH  - Brain Neoplasms/*genetics
MH  - Chromosomes, Human, Pair 17
MH  - *Chromosomes, Human, Pair 22
MH  - Female
MH  - Gene Deletion
MH  - Genes, p53/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Meningioma/*genetics
MH  - Middle Aged
MH  - Monosomy
MH  - *Mutation
MH  - Phenotype
EDAT- 2002/04/12 10:00
MHDA- 2002/06/11 10:01
CRDT- 2002/04/12 10:00
PHST- 2002/04/12 10:00 [pubmed]
PHST- 2002/06/11 10:01 [medline]
PHST- 2002/04/12 10:00 [entrez]
AID - 10.1002/tcm.10013 [pii]
AID - 10.1002/tcm.10013 [doi]
PST - ppublish
SO  - Teratog Carcinog Mutagen. 2002;22(3):217-25. doi: 10.1002/tcm.10013.