PMID- 11950809
OWN - NLM
STAT- MEDLINE
DCOM- 20020603
LR  - 20190501
IS  - 0017-5749 (Print)
IS  - 1458-3288 (Electronic)
IS  - 0017-5749 (Linking)
VI  - 50
IP  - 5
DP  - 2002 May
TI  - Plasma insulin-like growth factor 1, insulin-like growth factor binding protein 
      3, and risk of colorectal cancer: a prospective study in northern Sweden.
PG  - 642-6
AB  - BACKGROUND: Insulin-like growth factor 1 (IGF-1) has antiapoptotic and mitogenic 
      effects on various cell types, and raised IGF-1 levels are increasingly being 
      implicated as potential risk factors for cancer. AIMS: To examine the 
      relationship between IGF-1 and its major plasma binding protein, IGF binding 
      protein 3 (IGFBP-3), and the risk of colorectal cancer. METHODS: We conducted a 
      case-control study nested within the Northern Sweden Health and Disease Cohort. 
      IGF-1 and IGFBP-3 were measured in prediagnostic plasma samples from 168 men and 
      women who developed cancers of the colon (n=110) or rectum (n=58), and from 336 
      matched controls. RESULTS: Conditional logistic regression analyses showed an 
      increase in colon cancer risk with increasing levels of IGF-1 (odds ratios (ORs) 
      1.00, 1.89, 2.30, 2.66; p(trend)=0.03) and IGFBP-3 (ORs 1.00, 0.91, 1.80, 1.93; 
      p(trend)=0.02). Rectal cancer risk was inversely related to levels of IGF-1 (ORs 
      1.00, 0.45, 0.33, 0.33; p(trend)=0.09) and IGFBP-3 (ORs 1.00, 0.75, 0.66, 0.49; 
      p(trend)=0.21). Mutual adjustments between IGF-1 and IGFBP-3 did not materially 
      alter these relationships. CONCLUSIONS: These results support earlier findings of 
      increased risk of colon cancer in subjects with elevated plasma IGF-1. Our 
      results however do not support the hypothesis that the risk of rectal cancer 
      could also be directly related to IGF-1 levels.
FAU - Palmqvist, R
AU  - Palmqvist R
AD  - Department of Medical Biosciences, Pathology, Umea University, SE-901 87 Umea, 
      Sweden.
FAU - Hallmans, G
AU  - Hallmans G
FAU - Rinaldi, S
AU  - Rinaldi S
FAU - Biessy, C
AU  - Biessy C
FAU - Stenling, R
AU  - Stenling R
FAU - Riboli, E
AU  - Riboli E
FAU - Kaaks, R
AU  - Kaaks R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Gut
JT  - Gut
JID - 2985108R
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 0 (Neoplasm Proteins)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adult
MH  - Anthropometry
MH  - Case-Control Studies
MH  - Colonic Neoplasms/*blood
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/*analysis
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/*blood
MH  - Odds Ratio
MH  - Prospective Studies
MH  - Rectal Neoplasms/*blood
MH  - Risk Factors
PMC - PMC1773192
EDAT- 2002/04/16 10:00
MHDA- 2002/06/04 10:01
PMCR- 2005/05/01
CRDT- 2002/04/16 10:00
PHST- 2002/04/16 10:00 [pubmed]
PHST- 2002/06/04 10:01 [medline]
PHST- 2002/04/16 10:00 [entrez]
PHST- 2005/05/01 00:00 [pmc-release]
AID - 0500642 [pii]
AID - 10.1136/gut.50.5.642 [doi]
PST - ppublish
SO  - Gut. 2002 May;50(5):642-6. doi: 10.1136/gut.50.5.642.