PMID- 11953446
OWN - NLM
STAT- MEDLINE
DCOM- 20020419
LR  - 20190630
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 80
IP  - 6
DP  - 2002 Mar
TI  - Effect of depleting vesicular and cytoplasmic dopamine on 
      methylenedioxymethamphetamine neurotoxicity.
PG  - 960-9
AB  - The mechanism by which 3,4-methylenedioxymethamphetamine (MDMA) produces 
      serotonin (5-HT) neurotoxicity is unknown but considerable evidence suggests that 
      endogenous brain dopamine (DA) is involved. However, it has recently become 
      apparent that some of the data implicating brain DA in MDMA neurotoxicity may be 
      confounded by drug effects on thermoregulation. The purpose of the present 
      studies was to examine the role of DA in MDMA neurotoxicity, while controlling 
      for possible confounding effects of drug- induced changes in core temperature. 
      Rats were treated with reserpine, alone and in combination with alpha-methyl-p 
      -tyrosine (AMPT), to deplete vesicular and cytoplasmic stores of DA. When 
      drug-induced hypothermia was averted (by raising ambient temperature), the 5-HT 
      neuroprotective effects of reserpine and AMPT were no longer apparent. The lack 
      of neuroprotection by AMPT and reserpine, alone and in combination, in studies 
      that control for the effects of these drugs on core temperature, suggests that DA 
      per se is not essential for the expression of MDMA-induced 5-HT neurotoxicity.
FAU - Yuan, Jie
AU  - Yuan J
AD  - Departments of Neurology and Psychiatry, Johns Hopkins University School of 
      Medicine, Baltimore, Maryland 21224, USA.
FAU - Cord, Branden J
AU  - Cord BJ
FAU - McCann, Una D
AU  - McCann UD
FAU - Callahan, Brian T
AU  - Callahan BT
FAU - Ricaurte, George A
AU  - Ricaurte GA
LA  - eng
GR  - DA05707/DA/NIDA NIH HHS/United States
GR  - DA05938/DA/NIDA NIH HHS/United States
GR  - DA09487/DA/NIDA NIH HHS/United States
GR  - DA10217/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Serotonin Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - 658-48-0 (alpha-Methyltyrosine)
RN  - 8B1QWR724A (Reserpine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/pharmacology
MH  - Animals
MH  - Corpus Striatum/cytology/drug effects
MH  - Cytoplasm/*metabolism
MH  - Cytoplasmic Vesicles/*metabolism
MH  - Cytoprotection/drug effects
MH  - Dopamine/deficiency/*metabolism
MH  - Drug Synergism
MH  - Drug-Related Side Effects and Adverse Reactions/metabolism
MH  - Enzyme Inhibitors/pharmacology
MH  - Hippocampus/cytology/drug effects
MH  - Hypothermia/chemically induced/prevention & control
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Neurons/cytology/*drug effects/metabolism
MH  - Rats
MH  - Reserpine/pharmacology
MH  - Serotonin/metabolism/toxicity
MH  - Serotonin Agents/toxicity
MH  - Temperature
MH  - alpha-Methyltyrosine/pharmacology
EDAT- 2002/04/16 10:00
MHDA- 2002/04/20 10:01
CRDT- 2002/04/16 10:00
PHST- 2002/04/16 10:00 [pubmed]
PHST- 2002/04/20 10:01 [medline]
PHST- 2002/04/16 10:00 [entrez]
AID - 10.1046/j.0022-3042.2002.00758.x [doi]
PST - ppublish
SO  - J Neurochem. 2002 Mar;80(6):960-9. doi: 10.1046/j.0022-3042.2002.00758.x.