PMID- 11955470
OWN - NLM
STAT- MEDLINE
DCOM- 20020606
LR  - 20190815
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 51
IP  - 8
DP  - 2002 Apr 15
TI  - Three and six-month outcome following courses of either ECT or rTMS in a 
      population of severely depressed individuals--preliminary report.
PG  - 687-90
AB  - BACKGROUND: Recent studies have strengthened the claim that repetitive 
      transcranial magnetic stimulation (rTMS) is an effective treatment for major 
      depression. The longitudinal outcome of TMS-treated patients, however, has not 
      been described. We report on the 3- and 6-month outcomes of a group of patients 
      treated with either electroconvulsive therapy (ECT) (n = 20) or (rTMS) (n = 21). 
      METHODS: Patients diagnosed with major depressive disorder with or without 
      psychotic features referred for ECT were randomly assigned to receive either ECT 
      or rTMS. Forty-one patients who responded to either treatment constituted the 
      sample. Patients were followed on a monthly basis and outcomes were determined 
      with the Hamilton Rating Scale for Depression-17 items (HRSD) and the Global 
      Assessment of Functioning (GAF) scales. Medications were routinely prescribed. 
      RESULTS: There were no differences in the 6-month relapse rate between the 
      groups. Overall, 20% of the patients relapsed (four from the ECT group and four 
      from the rTMS group). Patients reported equally low and not significantly 
      different scores in the HRSD (ECT group 8.4 +/- 5.6 and TMS group 7.9 +/- 7.1) 
      and the GAF (ECT group 72.8 +/- 12 and TMS group 77.8 +/- 17.1) at the 6-month 
      follow up. CONCLUSIONS: Patients treated with rTMS do as well as those treated 
      with ECT at the 3- and 6-month follow-up points. These data suggest that the 
      clinical gains obtained with rTMS last at least as long as those obtained with 
      ECT.
FAU - Dannon, Pinhas N
AU  - Dannon PN
AD  - Psychiatry Division, ECT-TMS Unit, Chaim Sheba Medical Center, 52621 Tel 
      Hashomer, Israel.
FAU - Dolberg, Ornah T
AU  - Dolberg OT
FAU - Schreiber, Shaul
AU  - Schreiber S
FAU - Grunhaus, Leon
AU  - Grunhaus L
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
SB  - IM
MH  - Depressive Disorder, Major/psychology/*therapy
MH  - Electroconvulsive Therapy
MH  - Electromagnetic Fields
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Magnetics
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2002/04/17 10:00
MHDA- 2002/06/12 10:01
CRDT- 2002/04/17 10:00
PHST- 2002/04/17 10:00 [pubmed]
PHST- 2002/06/12 10:01 [medline]
PHST- 2002/04/17 10:00 [entrez]
AID - S0006322301012744 [pii]
AID - 10.1016/s0006-3223(01)01274-4 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2002 Apr 15;51(8):687-90. doi: 10.1016/s0006-3223(01)01274-4.