PMID- 11956863
OWN - NLM
STAT- MEDLINE
DCOM- 20020426
LR  - 20111117
IS  - 0931-041X (Print)
IS  - 0931-041X (Linking)
VI  - 17
IP  - 3
DP  - 2002 Mar
TI  - Increased HLA- A*11 in Chinese children with steroid-responsive nephrotic 
      syndrome.
PG  - 212-6
AB  - Human leukocyte antigen (HLA) associations have been frequently reported in 
      childhood steroid-responsive nephrotic syndrome (SRNS) in other populations. The 
      aim of this study was to characterize the immunogenetic background of Singaporean 
      Chinese patients with childhood SRNS. We determined the HLA class I (HLA- A* and 
      HLA-B*) as well as class II (HLA- DRB1*, HLA- DQB1*) gene polymorphisms using the 
      polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) technique, 
      in patients with SRNS (n=64) and normal controls (n=236 for HLA- A*, n=80 for 
      HLA- B*, HLA- DRB1* and HLA- DQB1*). The frequency of HLA- A*11 allele was 
      significantly higher in the SRNS patients compared to controls (78.1% vs 54.2%, 
      respectively; relative risk, RR=3.01, Pc=0.011). However, there was no 
      significant difference in the allele frequencies of HLA- B*, HLA- DRB1* and HLA- 
      DQB1* between the SRNS patients and controls, unlike that in previous studies. 
      Our data suggest that the immunogenetic background of Singaporean Chinese with 
      childhood SRNS was different from that in other populations. As HLA- A*11 has 
      been strongly associated with other autoimmune diseases, it is conceivable that 
      the HLA- A*11-specific motif may play a role in the development of the abnormal 
      T-cell-mediated immune response that may be responsible for triggering the 
      proteinuria seen in SRNS.
FAU - Cheung, Wai
AU  - Cheung W
AD  - Department of Pediatrics, National University of Singapore, 10 Lower Kent Ridge 
      Crescent, 119074, Singapore.
FAU - Ren, Ee-Chee
AU  - Ren EC
FAU - Chan, Soh-Ha
AU  - Chan SH
FAU - Gong, Wei-Kin
AU  - Gong WK
FAU - Yap, Hui-Kim
AU  - Yap HK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A11 Antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Oligonucleotide Probes)
SB  - IM
MH  - Adrenal Cortex Hormones/*therapeutic use
MH  - Child, Preschool
MH  - HLA-A Antigens/*metabolism
MH  - HLA-A11 Antigen
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Antigens Class II/genetics
MH  - Humans
MH  - Infant
MH  - Nephrotic Syndrome/drug therapy/genetics/*immunology
MH  - Oligonucleotide Probes
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
EDAT- 2002/04/17 10:00
MHDA- 2002/04/27 10:01
CRDT- 2002/04/17 10:00
PHST- 2002/04/17 10:00 [pubmed]
PHST- 2002/04/27 10:01 [medline]
PHST- 2002/04/17 10:00 [entrez]
AID - 10.1007/s00467-001-0800-3 [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2002 Mar;17(3):212-6. doi: 10.1007/s00467-001-0800-3.