PMID- 11956994
OWN - NLM
STAT- MEDLINE
DCOM- 20020502
LR  - 20171116
IS  - 0918-4287 (Print)
IS  - 0918-4287 (Linking)
VI  - 34
IP  - 4
DP  - 2001 Dec
TI  - Male germ cell death in mouse testes: possible involvement of Fas and Fas ligand.
PG  - 213-22
AB  - Loss of germ cells is very common during various stages of mammalian 
      spermatogenesis. Although cell death, particularly apoptosis, has been 
      implicated, our understanding of the mechanisms underlying germ cell death is 
      still limited. In order to elucidate the extent and mechanism of germ cell death, 
      this review first covers what is known of germ cell degeneration in the normal 
      testes of fetal, neonatal, and adult mice from electron microscopy (EM) and from 
      terminal dUTP nick-end labeling (TUNEL) staining. The issue of whether the Fas 
      and Fas ligand (FasL) system is involved in the induction of germ cell apoptosis 
      in normal and damaged testes is then addressed, including consideration of both 
      the ischemia-reperfusion model of testicular torsion and the estrogen-treated 
      testis model of environmental endocrine disruption. Finally, this review proposes 
      that different molecular pathways may be triggered to induce male germ cell 
      apoptosis, depending upon the physiological and pathological states of the germ 
      cells.
FAU - Koji, T
AU  - Koji T
AD  - Department of Histology and Cell Biology, Nagasaki University School of Medicine, 
      1-12-4 Sakamoto, Nagasaki 852-8523, Japan. tkoji@net.nagasaki-u.ac.jp
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Japan
TA  - Med Electron Microsc
JT  - Medical electron microscopy : official journal of the Clinical Electron 
      Microscopy Society of Japan
JID - 9430789
RN  - 0 (Fas Ligand Protein)
RN  - 0 (Fasl protein, mouse)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (fas Receptor)
SB  - IM
MH  - Animals
MH  - *Apoptosis
MH  - Fas Ligand Protein
MH  - Female
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - Membrane Glycoproteins/analysis/*physiology
MH  - Mice
MH  - Microscopy, Electron
MH  - Pregnancy
MH  - Reperfusion Injury/pathology
MH  - Spermatozoa/*pathology/ultrastructure
MH  - Testis/chemistry/*pathology
MH  - fas Receptor/analysis/*physiology
RF  - 57
EDAT- 2002/04/17 10:00
MHDA- 2002/05/03 10:01
CRDT- 2002/04/17 10:00
PHST- 2002/04/17 10:00 [pubmed]
PHST- 2002/05/03 10:01 [medline]
PHST- 2002/04/17 10:00 [entrez]
AID - 10.1007/s007950100018 [doi]
PST - ppublish
SO  - Med Electron Microsc. 2001 Dec;34(4):213-22. doi: 10.1007/s007950100018.