PMID- 11957046
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1436-3305 (Electronic)
IS  - 1436-3291 (Linking)
VI  - 1
IP  - 1
DP  - 1998 Dec
TI  - Expression of HLA-DR and urokinase-type plasminogen activator in stage IV gastric 
      cancer.
PG  - 71-77
AB  - BACKGROUND: Some patients with stage IV gastric cancer have a long survival. Host 
      immune response and proteolytic activity in the primary tumor may be associated 
      with outcome in these patients. The purpose of this study was to assess 
      prognostic factors in patients with stage IV far advanced gastric cancer.METHODS: 
      Findings in 26 patients who underwent resection of stage IV gastric cancer were 
      retrospectively analyzed for clinicopathological variables, and for the 
      immunohistochemical expression of human leukocyte antigen (HLA)-DR as an index of 
      host immune response and for expression of urokinase type-plasminogen activator 
      (u-PA) as an index of proteolytic activity in the tumor.RESULTS: Of the 13 
      clinicopathological and immunohistochemical variables tested by univariate 
      analysis surgical curability, lymph node metastasis, HLA-DR expression, and u-PA 
      expression had a significant influence on survival after surgery. Multivariate 
      analysis showed that surgical curability, HLA-DR expression, and u-PA expression 
      independently influenced survival. Patients positive for HLA-DR expression 
      [HLA-DR (+)] and regative for u-PA expression [u-PA (-)] had the best survival: 
      25-month median survival and 25% 5-year survival rate. Patients who were HLA-DR 
      (+) and u-PA (+), or HLA-DR (-) and u-PA (-) had a median survival of 10 months, 
      a 1-year survival rate of 46.2%, and a 2-year survival rate of 7.7%. HLA-DR (-) 
      and u-PA (+) patients had the worst survival: 4.5-month median survival and 0% 
      1-year survival.CONCLUSIONS: These findings suggest that host immune response and 
      proteolytic activity in the primary tumor may determine malignant potential, and 
      that the combination of positive-HLA-DR and negative-u-PA expression in cancer 
      cells may be a predictor of prolonged survival in stage IV gastric cancer 
      patients.
FAU - Murata, Satoshi
AU  - Murata S
AD  - First Department of Surgery, Shiga University of Medical Science, Tsukinowa-cho, 
      Seta, Otsu, Shiga 520-2192, Japan.
FAU - Eguchi, Yutaka
AU  - Eguchi Y
FAU - Terata, Nobukuni
AU  - Terata N
FAU - Tani, Tohru
AU  - Tani T
FAU - Kodama, Masashi
AU  - Kodama M
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Gastric Cancer
JT  - Gastric cancer : official journal of the International Gastric Cancer Association 
      and the Japanese Gastric Cancer Association
JID - 100886238
EDAT- 2002/04/17 10:00
MHDA- 2002/04/17 10:01
CRDT- 2002/04/17 10:00
PHST- 2002/04/17 10:00 [pubmed]
PHST- 2002/04/17 10:01 [medline]
PHST- 2002/04/17 10:00 [entrez]
AID - 10.1007/s101200050057 [doi]
PST - ppublish
SO  - Gastric Cancer. 1998 Dec;1(1):71-77. doi: 10.1007/s101200050057.