PMID- 11958823
OWN - NLM
STAT- MEDLINE
DCOM- 20020502
LR  - 20220129
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 124
IP  - 1-2
DP  - 2002 Mar
TI  - Brain-derived neurotrophic factor in experimental autoimmune neuritis.
PG  - 62-9
AB  - Long-term disability in Guillain-Barre syndrome (GBS) is associated with axonal, 
      and some neuronal, degeneration. Brain-derived neurotrophic factor (BDNF) can 
      prevent neuronal death following damage to motor axons and we have therefore 
      examined the ability of BDNF to ameliorate the effects of experimental autoimmune 
      neuritis (EAN), a model of GBS. Treatment of Lewis rats with BDNF (10 mg/kg/day) 
      did not significantly affect the neurological deficit, nor significantly improve 
      survival, motor function or motor innervation. The weight of the urinary bladder 
      was significantly increased in control animals with EAN, but remained similar to 
      normal in animals treated with BDNF. With the exception of a possibly protective 
      effect indicated by bladder weight, this study suggests that BDNF may not provide 
      an effective therapy for GBS, at least in the acute phase of the disease.
FAU - Felts, Paul A
AU  - Felts PA
AD  - Department of Neuroimmunology and the Neuroinflammation Research Group, Guy's, 
      King's and St. Thomas' School of Medicine, King's College London, Guy's Campus, 
      London SE1 1UL, UK. paul.felts@kcl.ac.uk
FAU - Smith, Kenneth J
AU  - Smith KJ
FAU - Gregson, Norman A
AU  - Gregson NA
FAU - Hughes, Richard A C
AU  - Hughes RA
LA  - eng
GR  - 592/MSS_/Multiple Sclerosis Society/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Antibodies)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.3.1.6 (Choline O-Acetyltransferase)
SB  - IM
MH  - Animals
MH  - Antibodies/analysis
MH  - Brain-Derived Neurotrophic Factor/immunology/*therapeutic use
MH  - Choline O-Acetyltransferase/metabolism
MH  - Hand Strength
MH  - Histocytochemistry
MH  - Male
MH  - Motor Activity/drug effects
MH  - Motor Endplate/enzymology/ultrastructure
MH  - Muscle, Skeletal/enzymology/ultrastructure
MH  - Neuritis, Autoimmune, Experimental/*drug therapy/physiopathology
MH  - Organ Size/drug effects
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Treatment Failure
MH  - Urinary Bladder/drug effects/pathology
EDAT- 2002/04/18 10:00
MHDA- 2002/05/03 10:01
CRDT- 2002/04/18 10:00
PHST- 2002/04/18 10:00 [pubmed]
PHST- 2002/05/03 10:01 [medline]
PHST- 2002/04/18 10:00 [entrez]
AID - S0165572802000176 [pii]
AID - 10.1016/s0165-5728(02)00017-6 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2002 Mar;124(1-2):62-9. doi: 10.1016/s0165-5728(02)00017-6.