PMID- 11958886
OWN - NLM
STAT- MEDLINE
DCOM- 20021001
LR  - 20190708
IS  - 0360-3016 (Print)
IS  - 0360-3016 (Linking)
VI  - 52
IP  - 4
DP  - 2002 Mar 15
TI  - Subcutaneous fibrosis after whole neck irradiation.
PG  - 937-43
AB  - PURPOSE: To identify the risk factors for moderate to severe subcutaneous 
      fibrosis after whole neck irradiation. MATERIALS AND METHODS: We analyzed 233 
      cases of patients who had undergone whole neck irradiation with 4-MV X-ray or 
      8-10-MeV electrons, or both, and had been followed with regard to their skin 
      condition for at least 1 year. The prescribed dose to the whole neck ranged from 
      19.2 to 72.4 Gy (median 50). The skin-absorbed dose was specified as that at a 
      depth of 4.1 mm (d4.1-mm(depth)), and a biologically equivalent dose (BED) of 
      d4.1-mm(depth) was also estimated (BED(1.8) 4.1-mm(depth)). RESULTS: Univariate 
      analysis revealed that previous neck dissection, concurrent chemotherapy, 
      corticosteroid administration as a part of chemotherapy, fractionation, and 
      BED(1.8) 4.1-mm(depth) were significant prognostic variables. Multivariate 
      analysis showed that BED(1.8) 4.1-mm(depth) and previous neck dissection were the 
      only prognostic variables for moderate to severe subcutaneous fibrosis. 
      CONCLUSION: A high dose to a 4.1-mm depth of the skin and a history of neck 
      dissection were identified as the predominant risk factors for moderate to severe 
      subcutaneous fibrosis after whole neck irradiation. A subcutaneous dose should be 
      considered in radiotherapy treatment planning involving the whole neck, 
      especially in cases in which patients have undergone previous neck dissection.
FAU - Hirota, Saeko
AU  - Hirota S
AD  - Department of Radiology, Hyogo Medical Center for Adults, Akashi, Japan. 
      ka3s-hrt@asahi-net.or.jp
FAU - Tsujino, Kayoko
AU  - Tsujino K
FAU - Oshitani, Takashi
AU  - Oshitani T
FAU - Hishikawa, Yoshio
AU  - Hishikawa Y
FAU - Takada, Yoshiki
AU  - Takada Y
FAU - Kono, Michio
AU  - Kono M
FAU - Abe, Mitsuyuki
AU  - Abe M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Fibrosis
MH  - Head and Neck Neoplasms/*radiotherapy
MH  - Humans
MH  - Lymph Node Excision
MH  - Middle Aged
MH  - Neck
MH  - Radiation Injuries/*pathology
MH  - Retrospective Studies
MH  - Skin/*pathology/radiation effects
EDAT- 2002/04/18 10:00
MHDA- 2002/10/03 04:00
CRDT- 2002/04/18 10:00
PHST- 2002/04/18 10:00 [pubmed]
PHST- 2002/10/03 04:00 [medline]
PHST- 2002/04/18 10:00 [entrez]
AID - S0360301601027353 [pii]
AID - 10.1016/s0360-3016(01)02735-3 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2002 Mar 15;52(4):937-43. doi: 
      10.1016/s0360-3016(01)02735-3.