PMID- 11958905
OWN - NLM
STAT- MEDLINE
DCOM- 20021001
LR  - 20220316
IS  - 0360-3016 (Print)
IS  - 0360-3016 (Linking)
VI  - 52
IP  - 4
DP  - 2002 Mar 15
TI  - Palliative radiation for vertebral metastases: the effect of variation in 
      prescription parameters on the dose received at depth.
PG  - 1083-91
AB  - PURPOSE: To assess the effect of prescription parameters on the dose received by 
      the spine during palliative radiotherapy. MATERIALS AND METHODS: In a survey, 
      members of the Canadian Association of Radiation Oncologists were asked to define 
      their prescription parameters for vertebral metastases. The depth of the spinal 
      canal and vertebral body at 8 spinal levels was measured in 20 magnetic resonance 
      imaging studies (MRIs). Survey results were applied to the measurements to assess 
      the dose received at depth. The depth of spinal structures assessed at simulation 
      and by diagnostic imaging was compared. RESULTS: Prescriptions were most commonly 
      to D(max) 3 cm or 5 cm using 60Co-6MV photons delivering 8-30 Gy in 1-10 
      fractions. Mean depths from MRI were: posterior spinal canal, 5.5 cm; anterior 
      spinal canal, 6.9 cm; and anterior vertebral body, 9.6 cm. Application of the 
      prescription parameters from the survey to these measurements showed a wide range 
      in the dose at depth with variation in technique. Depths measured at simulation 
      correlated well with diagnostic imaging. CONCLUSION: The spinal canal and 
      vertebral body lie >5 cm beneath the skin, and the dose received varies by up to 
      50% with changes in prescription depth. We suggest a suitable prescription point 
      for vertebral metastases and a method for determining this at simulation.
FAU - Barton, Rachael
AU  - Barton R
AD  - Palliative Radiation Oncology Program, Princess Margaret Hospital, University 
      Health Network, University of Toronto, Toronto, Canada. 
      rachaelbarton@doctors.org.uk
FAU - Robinson, Graham
AU  - Robinson G
FAU - Gutierrez, Eric
AU  - Gutierrez E
FAU - Kirkbride, Peter
AU  - Kirkbride P
FAU - McLean, Michael
AU  - McLean M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
RN  - 0 (Cobalt Radioisotopes)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Canada
MH  - Cobalt Radioisotopes/therapeutic use
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Middle Aged
MH  - Pain/radiotherapy
MH  - *Palliative Care
MH  - Radiation Oncology/*standards
MH  - Radiotherapy Dosage
MH  - Spinal Neoplasms/*radiotherapy/*secondary
MH  - Spine/*anatomy & histology
MH  - Surveys and Questionnaires
EDAT- 2002/04/18 10:00
MHDA- 2002/10/03 04:00
CRDT- 2002/04/18 10:00
PHST- 2002/04/18 10:00 [pubmed]
PHST- 2002/10/03 04:00 [medline]
PHST- 2002/04/18 10:00 [entrez]
AID - S0360301601027389 [pii]
AID - 10.1016/s0360-3016(01)02738-9 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2002 Mar 15;52(4):1083-91. doi: 
      10.1016/s0360-3016(01)02738-9.