PMID- 11960210
OWN - NLM
STAT- MEDLINE
DCOM- 20020905
LR  - 20061115
IS  - 0364-2313 (Print)
IS  - 0364-2313 (Linking)
VI  - 26
IP  - 7
DP  - 2002 Jul
TI  - Deletion of chromosome 1, but not mutation of MEN-1, predicts prognosis in 
      sporadic pancreatic endocrine tumors.
PG  - 843-7
AB  - Pancreatic endocrine tumors (PETs) may be sporadic or inherited in the multiple 
      endocrine neoplasia type 1 (MEN-1) syndrome. The inherited form is caused by 
      mutations of the MEN-1 gene, which functions as a tumor suppressor gene and maps 
      to chromosome 11q13. These tumors tend to have a better prognosis than their 
      sporadic counterparts, which often have mutations of the MEN-1 gene. Previous 
      molecular analyses of sporadic PETs suggest a high frequency of loss of 
      heterozygosity (LOH) at chromosome 1 as well as mutation of MEN-1. In this study 
      we correlate abnormalities of MEN-1 and chromosome 1 LOH with the biological 
      behavior of sporadic PETs. Loss of heterozygosity for markers at chromosome 11q13 
      and mutation of MEN-1 were equally frequent in tumors with or without liver 
      metastases. Mutation of MEN-1 is more frequent in gastrinomas than in 
      non-gastrinomas. Loss of heterozygosity for markers on chromosome 1 is more 
      frequent in PETs with liver metastases. These results suggest a molecular tumor 
      model in which there is a dichotomy in the development of benign and malignant 
      PETs.
FAU - Guo, Sydney S
AU  - Guo SS
AD  - Department of Surgery, West Los Angeles VA Medical Center and the UCLA School of 
      Medicine, Los Angeles, CA 90073, USA.
FAU - Wu, Alan Y
AU  - Wu AY
FAU - Sawicki, Mark P
AU  - Sawicki MP
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20020418
PL  - United States
TA  - World J Surg
JT  - World journal of surgery
JID - 7704052
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Adenoma, Islet Cell/diagnosis/*genetics/pathology
MH  - Carcinoma, Islet Cell/diagnosis/genetics/pathology
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Humans
MH  - Liver Neoplasms/secondary
MH  - Loss of Heterozygosity
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Mutation
MH  - Neoplasm Metastasis
MH  - Neoplasm Proteins/*genetics
MH  - Pancreatic Neoplasms/diagnosis/*genetics/pathology
MH  - Prognosis
MH  - *Proto-Oncogene Proteins
EDAT- 2002/04/18 10:00
MHDA- 2002/09/06 10:01
CRDT- 2002/04/18 10:00
PHST- 2002/04/18 10:00 [pubmed]
PHST- 2002/09/06 10:01 [medline]
PHST- 2002/04/18 10:00 [entrez]
AID - 10.1007/s00268-002-4062-4 [doi]
PST - ppublish
SO  - World J Surg. 2002 Jul;26(7):843-7. doi: 10.1007/s00268-002-4062-4. Epub 2002 Apr 
      18.