PMID- 11960354
OWN - NLM
STAT- MEDLINE
DCOM- 20020507
LR  - 20130304
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 16
IP  - 4
DP  - 2002 Apr
TI  - Antibody status to HHV-6 in children with leukaemia.
PG  - 716-9
AB  - Forty children with acute lymphoblastic (33) or myeloid leukaemia (seven) were 
      studied for IgG and IgM antibodies and IgG avidity against human herpesvirus 6 
      (HHV-6) at the time of diagnosis, and compared with age-, sex- and season-matched 
      children with various neurological diseases of suspected viral origin. Of the 
      children with leukaemia, 97.5% had IgG antibodies and 40% IgM antibodies to HHV-6 
      compared with 92.3% and 7.7% of reference subjects (P = 0.005). A seronegative 
      child with leukaemia seroconverted 3 weeks after the diagnosis. The avidity of 
      IgG antibodies (based on the resistance to urea treatment) was high in all 
      children with leukaemia. One reference child had HHV-6-specific IgG antibodies 
      with low avidity, which together with his positive IgM indicated an acute 
      infection. The presence of specific IgM antibodies in 40% of children with 
      leukaemia and the high avidity of IgG suggest a reactivation or an inaproppriate 
      primary response to HHV-6 infection. The results support the conclusion of the 
      role of the HHV-6 infection at the onset of childhood leukaemia.
FAU - Salonen, M J H
AU  - Salonen MJ
AD  - Haartman Institute, Department of Virology, University of Helsinki, Helsinki, 
      Finland.
FAU - Siimes, M A
AU  - Siimes MA
FAU - Salonen, E-M
AU  - Salonen EM
FAU - Vaheri, A
AU  - Vaheri A
FAU - Koskiniemi, M
AU  - Koskiniemi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (Antibodies, Viral)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Antibodies, Viral/*blood
MH  - Child
MH  - Child, Preschool
MH  - Exanthema Subitum/*immunology/virology
MH  - Female
MH  - Herpesvirus 6, Human/*immunology
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Immunoglobulin M/*analysis
MH  - Infant
MH  - Leukemia, Myeloid, Acute/*immunology/virology
MH  - Male
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*immunology/virology
EDAT- 2002/04/18 10:00
MHDA- 2002/05/08 10:01
CRDT- 2002/04/18 10:00
PHST- 2001/07/06 00:00 [received]
PHST- 2001/11/20 00:00 [accepted]
PHST- 2002/04/18 10:00 [pubmed]
PHST- 2002/05/08 10:01 [medline]
PHST- 2002/04/18 10:00 [entrez]
AID - 10.1038/sj.leu.2402437 [doi]
PST - ppublish
SO  - Leukemia. 2002 Apr;16(4):716-9. doi: 10.1038/sj.leu.2402437.