PMID- 11961336
OWN - NLM
STAT- MEDLINE
DCOM- 20030226
LR  - 20181130
IS  - 0012-2823 (Print)
IS  - 0012-2823 (Linking)
VI  - 65
IP  - 1
DP  - 2002
TI  - Effect of omeprazole on regional and temporal variations in intragastric acidity.
PG  - 2-10
AB  - BACKGROUND: Conventional techniques for measuring gastric acidity have 
      demonstrated the decrease in gastric acidity produced by proton pump inhibitors 
      (PPI); however, such techniques do not detect transient or localized pH changes 
      which may modify the intragastric environment without affecting the therapeutic 
      efficacy of PPIs. AIM: To investigate local and temporal variations in 
      intragastric pH and to test the hypothesis that omeprazole produces prolonged, 
      generalized gastric anacidity (pH >6). METHODS: A single-blind study was 
      conducted with triple-point 24-hour gastric pH-metry on days 7, 14 and 21 in 14 
      healthy, Helicobacter pylori-negative volunteers (7 M; 20-46 years) who received 
      placebo for 7 days, followed by omeprazole 20 mg daily for 14 days. RESULTS: 
      Omeprazole increased the median 24-hour pH significantly in the distal corpus 
      (placebo: 1.3 (95% CI 1.1 to 1.6); omeprazole week 1: 4.0 (2.6-5.0); omeprazole 
      week 2: 4.0 (2.8-4.6)) and at all other gastric recording sites (p < 0.01). At 
      both corpus sites, nocturnal pH was lower and mealtime pH was higher than the 
      non-meal daytime pH during placebo and both omeprazole administration periods; in 
      the antrum, however, the major difference noted was that meal-time pH was higher 
      than non-meal daytime pH. Antral pH was lower during meals and higher at night 
      than proximal corpus pH. During placebo, gastric pH >6.0 was observed at 1 site 
      only for 1.7% (median; 95% CI 0.4-3.3%), at 2 sites simultaneously for 0.24% 
      (0.0-1.0%) and at 3 sites for 0.0% (0.0-0.28%), respectively, of the recording 
      periods; during the second week of omeprazole, the equivalent results were 7.7% 
      (1.4-14.0%), 4.9% (0.21-15.7%) and 4.7% (0.0-9.9%), respectively. CONCLUSIONS: 
      Omeprazole, 20 mg daily, does not produce gastric anacidity despite significant 
      increases in median 24-hour pH values. The time-, meal- and site-related 
      variations in gastric pH observed under normal physiological conditions are seen 
      to persist, with prolonged periods of low pH throughout the stomach and 
      preservation of the normal, meal-related rise and nocturnal fall in gastric pH 
      during omeprazole administration.
CI  - Copyright 2002 S. Karger AG, Basel
FAU - Viani, F
AU  - Viani F
AD  - Division de Gastroenterologie, CHUV/PMU, Lausanne, Switzerland.
FAU - Verdu, E F
AU  - Verdu EF
FAU - Idstrom, J P
AU  - Idstrom JP
FAU - Cederberg, C
AU  - Cederberg C
FAU - Fraser, R
AU  - Fraser R
FAU - Fried, M
AU  - Fried M
FAU - Blum, A L
AU  - Blum AL
FAU - Armstrong, D
AU  - Armstrong D
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Digestion
JT  - Digestion
JID - 0150472
RN  - 0 (Enzyme Inhibitors)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - Circadian Rhythm
MH  - Electrodes
MH  - Enzyme Inhibitors/administration & dosage/*pharmacology
MH  - Female
MH  - Gastric Acid/metabolism
MH  - Gastric Acidity Determination
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Male
MH  - Omeprazole/administration & dosage/*pharmacology
MH  - Single-Blind Method
EDAT- 2002/04/19 10:00
MHDA- 2003/02/27 04:00
CRDT- 2002/04/19 10:00
PHST- 2002/04/19 10:00 [pubmed]
PHST- 2003/02/27 04:00 [medline]
PHST- 2002/04/19 10:00 [entrez]
AID - 51924 [pii]
AID - 10.1159/000051924 [doi]
PST - ppublish
SO  - Digestion. 2002;65(1):2-10. doi: 10.1159/000051924.