PMID- 11962538
OWN - NLM
STAT- MEDLINE
DCOM- 20020507
LR  - 20041117
IS  - 0944-7113 (Print)
IS  - 0944-7113 (Linking)
VI  - 6
IP  - 5
DP  - 1999 Nov
TI  - Prevention of psychological stress-induced immune suppression by aged garlic 
      extract.
PG  - 325-30
AB  - We determined the effect of Aged Garlic Extract (AGE) on damage caused to immune 
      function by a psychological stress using a communication box. After four days of 
      a psychological stress, a decrease in spleen weight and spleen cells was observed 
      in the psychological stress-exposed mice as compared normal mice (non-stress). 
      AGE significantly prevented the decreases in spleen weight and cells. 
      Additionally, AGE significantly prevented the reduction of hemolytic 
      plaque-forming-cells in spleen cells and anti-SRBC antibody titer in serum caused 
      by this psychological stress. Moreover, a reduction in NK activities was observed 
      in the psychological stress-exposed mice as compared with normal mice 
      (non-stress), whereas NK activities in the AGE administered mice were almost the 
      same as normal mice (non-stress). These results indicate that psychological 
      stress qualitatively and quantitatively impairs immune function, and that AGE is 
      extremely useful for preventing psychologically-induced damage.
FAU - Kyo, E
AU  - Kyo E
AD  - Pharmacology & Safety Assessment Laboratory of Healthcare Research Institute 
      Wakunaga Pharmaceutical Co, Ltd, Taketa-gun, Hiroshima, Japan. 
      XLT00713@niftyserve.or.jp
FAU - Uda, N
AU  - Uda N
FAU - Ushijima, M
AU  - Ushijima M
FAU - Kasuga, S
AU  - Kasuga S
FAU - Itakura, Y
AU  - Itakura Y
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Phytomedicine
JT  - Phytomedicine : international journal of phytotherapy and phytopharmacology
JID - 9438794
RN  - 0 (Antibodies)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Animals
MH  - Antibodies/blood/immunology
MH  - Enzyme Activation/drug effects
MH  - *Garlic
MH  - Immune Tolerance/drug effects/immunology
MH  - Killer Cells, Natural/drug effects/immunology
MH  - Lymphocyte Count
MH  - Male
MH  - *Mice
MH  - Organ Size/drug effects
MH  - Phytotherapy
MH  - Plant Extracts/immunology/pharmacology
MH  - *Plants, Medicinal
MH  - Spleen/cytology/drug effects/immunology/physiopathology
MH  - Stress, Psychological/drug therapy/*immunology/*physiopathology
EDAT- 2002/04/19 10:00
MHDA- 2002/05/08 10:01
CRDT- 2002/04/19 10:00
PHST- 2002/04/19 10:00 [pubmed]
PHST- 2002/05/08 10:01 [medline]
PHST- 2002/04/19 10:00 [entrez]
AID - S0944-7113(99)80053-1 [pii]
AID - 10.1016/S0944-7113(99)80053-1 [doi]
PST - ppublish
SO  - Phytomedicine. 1999 Nov;6(5):325-30. doi: 10.1016/S0944-7113(99)80053-1.