PMID- 11967592
OWN - NLM
STAT- MEDLINE
DCOM- 20020801
LR  - 20061115
IS  - 0342-4642 (Print)
IS  - 0342-4642 (Linking)
VI  - 28
IP  - 4
DP  - 2002 Apr
TI  - Cardiac output measurement by pulse dye densitometry: a comparison with the 
      Fick's principle and thermodilution method.
PG  - 399-405
AB  - OBJECTIVE: To evaluate the agreement between cardiac output (CO) measurements 
      obtained by a new dye dilution technique using pulse dye densitometry (PDD) and 
      thermodilution (TD) and the direct Fick method (F). DESIGN AND SETTING: 
      Prospective clinical study in a university hospital, cardiac surgery intensive 
      care unit. PATIENTS: Fifty-eight cardiac surgery patients after admission to the 
      intensive care unit (six were excluded due to a low pulse signal quality using 
      the PDD method). MEASUREMENTS AND RESULTS: Mean CO was 5.3+/-1.8 l/min for PDD, 
      5.7+/-1.68 l/min for TD, and 6.16+/-1.66 l/min for F. There was a good 
      correlation between PDD and TD ( r(2)=0.93) and between PDD and F ( r(2)=0.77). 
      Bias and precision between PDD and TD were -0.39+/-0.5 l/min and -0.69+/-0.85 
      l/min between PDD and F. In general, PDD determined lower CO values than TD and 
      F. Especially in patients with CO below 5 l/min PDD underestimated CO in 
      comparison to TD and F (bias and precision: -0.51+/-0.40 l/min and -0.83+/-1.0 
      l/min). CONCLUSION: Comparison between PDD and TD showed good agreement for the 
      normal to high CO range. However, agreement was poor in patients with low CO. In 
      the latter patient group PDD showed relevant underestimation of CO compared to TD 
      and F. Due to these limitations PDD cannot entirely replace the pulmonary artery 
      catheter for CO determination.
FAU - Bremer, Frank
AU  - Bremer F
AD  - Department of Anesthesiology, Friedrich Alexander University Erlangen-Nuremberg, 
      Krankenhausstrasse 12, 91054 Erlangen, Germany. 
      frank.bremer@kfa.imed.uni-erlangen.de
FAU - Schiele, Albert
AU  - Schiele A
FAU - Tschaikowsky, Klaus
AU  - Tschaikowsky K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20020315
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
SB  - IM
MH  - Adult
MH  - Aged
MH  - Algorithms
MH  - Analysis of Variance
MH  - *Cardiac Output
MH  - Cardiac Surgical Procedures
MH  - Densitometry/methods
MH  - *Dye Dilution Technique
MH  - Humans
MH  - Prospective Studies
MH  - Thermodilution/*methods
EDAT- 2002/04/23 10:00
MHDA- 2002/08/02 10:01
CRDT- 2002/04/23 10:00
PHST- 2001/07/16 00:00 [received]
PHST- 2002/01/24 00:00 [accepted]
PHST- 2002/04/23 10:00 [pubmed]
PHST- 2002/08/02 10:01 [medline]
PHST- 2002/04/23 10:00 [entrez]
AID - 10.1007/s00134-002-1252-3 [doi]
PST - ppublish
SO  - Intensive Care Med. 2002 Apr;28(4):399-405. doi: 10.1007/s00134-002-1252-3. Epub 
      2002 Mar 15.