PMID- 11972099
OWN - NLM
STAT- MEDLINE
DCOM- 20020614
LR  - 20190916
IS  - 1077-4114 (Print)
IS  - 1077-4114 (Linking)
VI  - 24
IP  - 4
DP  - 2002 May
TI  - Transient erythroblastopenia of childhood: prospective study of 10 patients with 
      special reference to viral infections.
PG  - 294-8
AB  - PURPOSE: It has been proposed that human parvovirus B19 or human herpesvirus 6 
      (HHV-6) causes transient erythroblastopenia of childhood (TEC). This study was 
      performed prospectively and accurately in a sufficiently large population to 
      confirm or reject these suggestions, or possibly to find another causative agent 
      for TEC. PATIENTS AND METHODS: The authors studied prospectively the causative 
      aspects of 10 consecutive children with TEC presenting at five Swedish pediatric 
      clinics from 1994 to 1998 using serologic assays and polymerase chain reaction 
      assays for B19, HHV-6, cytomegalovirus, and Epstein-Barr virus (EBV). The authors 
      also performed isolation investigations of virus from bone marrow, stools, and 
      aspirate from the nasopharynx. RESULTS: The authors found acute EBV infection in 
      one child. There were no other instances of IgM positivity for any viruses at 
      presentation, but a few children did show IgG positivity to HHV-6 (n = 2), EBV (n 
      = 1), and cytomegalovirus (n = 1). No children were positive with respect to IgG 
      for B19. However, it could not be determined when these children had been 
      infected, and thus, a connection to TEC cannot be proved or excluded. No child 
      showed B19 or HHV-6 DNA in serum or bone marrow collected at presentation. 
      Isolation of virus from bone marrow, stools, and aspirate from nasopharynx 
      culture was negative in all children but one, who had rotavirus in stool. 
      CONCLUSIONS: HHV-6, B19, EBV, and cytomegalovirus are not common causative agents 
      of TEC. The authors found no proof of any single agent causing TEC.
FAU - Skeppner, Gunnar
AU  - Skeppner G
AD  - Department of Pediatrics, Orebro Medical Center Hospital, Orebro, Sweden. 
      gunnar.skeppner@telia.com
FAU - Kreuger, Anders
AU  - Kreuger A
FAU - Elinder, Goran
AU  - Elinder G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pediatr Hematol Oncol
JT  - Journal of pediatric hematology/oncology
JID - 9505928
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Viral)
RN  - 0 (Immunoglobulins)
SB  - IM
MH  - Anemia/*virology
MH  - Antibodies, Viral/analysis
MH  - Bone Marrow/pathology/virology
MH  - Child, Preschool
MH  - Cytomegalovirus/genetics/immunology/isolation & purification
MH  - DNA Primers/chemistry
MH  - DNA, Viral/analysis
MH  - Epstein-Barr Virus Infections/virology
MH  - Erythroblasts/*virology
MH  - Female
MH  - Flow Cytometry
MH  - Herpesviridae Infections/virology
MH  - Herpesvirus 4, Human/genetics/immunology/isolation & purification
MH  - Herpesvirus 6, Human/genetics/immunology/isolation & purification
MH  - Humans
MH  - Immunoglobulins/analysis
MH  - Infant
MH  - Male
MH  - Parvoviridae Infections/virology
MH  - Parvovirus B19, Human/genetics/immunology/isolation & purification
MH  - Polymerase Chain Reaction
MH  - Prospective Studies
EDAT- 2002/04/25 10:00
MHDA- 2002/06/18 10:01
CRDT- 2002/04/25 10:00
PHST- 2002/04/25 10:00 [pubmed]
PHST- 2002/06/18 10:01 [medline]
PHST- 2002/04/25 10:00 [entrez]
AID - 10.1097/00043426-200205000-00015 [doi]
PST - ppublish
SO  - J Pediatr Hematol Oncol. 2002 May;24(4):294-8. doi: 
      10.1097/00043426-200205000-00015.