PMID- 11975987
OWN - NLM
STAT- MEDLINE
DCOM- 20021009
LR  - 20221207
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 63
IP  - 5
DP  - 2002 May
TI  - Central MHC genes affect IgA levels in the human: reciprocal effects in IgA 
      deficiency and IgA nephropathy.
PG  - 424-33
AB  - This study investigates the hypothesis that alternative alleles of one or more 
      genes in the central major histocompatibility complex (MHC) predispose carriers 
      to IgA deficiency (IgAD) or IgA Nephropathy (IgAN). Australian caucasian IgAD, 
      IgAN patients, and controls were typed at HLA loci, single nucleotide 
      polymorphisms, and microsatellites in the MHC. Alleles of the D6S273 
      microsatellite exhibited strong associations with IgAD and IgAN. D6S273*129 and 
      *139 were more frequent in IgAD and less frequent in IgAN patients than controls. 
      The reverse was true for D6S273*133 and *131. Alleles of other microsatellites 
      exhibited weak associations with IgAD or IgAN. D6S273*129 is found on the 65.1 
      ancestral haplotype [HLA-B14(65),DR1], which has been reported to be increased in 
      IgAD, but the majority of IgAD patients with D6S273*129 did not have other 
      alleles of the haplotype. D6S273*139 is characteristic of the 8.1 ancestral 
      haplotype (HLA-A1,B8,DR3), which was common in IgAD and rare in IgAN patients. 
      Further studies of the 8.1 haplotype in Australian, German and Spanish caucasian 
      subjects revealed that HLA-DR3, in the absence of -B8, is not associated with 
      IgAD. However -B8 is associated with IgAD in the absence of -DR3, consistent with 
      a susceptibility locus in the central MHC. Provisional mapping within this region 
      is discussed.
FAU - Matthews, Vance B
AU  - Matthews VB
AD  - Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, 
      Australia. vmatthews@biochem.uni-kiel.de
FAU - Witt, Campbell S
AU  - Witt CS
FAU - French, Martyn A H
AU  - French MA
FAU - Machulla, Helmut K G
AU  - Machulla HK
FAU - De la Concha, Emilio G
AU  - De la Concha EG
FAU - Cheong, Karey Y
AU  - Cheong KY
FAU - Vigil, Patricia
AU  - Vigil P
FAU - Hollingsworth, Peter N
AU  - Hollingsworth PN
FAU - Warr, Kevin J
AU  - Warr KJ
FAU - Christiansen, Frank T
AU  - Christiansen FT
FAU - Price, Patricia
AU  - Price P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-B8 Antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (HLA-DR8 antigen)
RN  - 0 (Immunoglobulin A)
SB  - IM
MH  - Australia
MH  - Cohort Studies
MH  - *Genetic Predisposition to Disease
MH  - Glomerulonephritis, IGA/*genetics
MH  - HLA-B8 Antigen/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DR Serological Subtypes
MH  - HLA-DR3 Antigen/genetics
MH  - Haplotypes
MH  - Humans
MH  - IgA Deficiency/*genetics
MH  - Immunoglobulin A/analysis
MH  - Major Histocompatibility Complex/*genetics
MH  - Telomere/genetics
MH  - White People
EDAT- 2002/04/27 10:00
MHDA- 2002/10/10 04:00
CRDT- 2002/04/27 10:00
PHST- 2002/04/27 10:00 [pubmed]
PHST- 2002/10/10 04:00 [medline]
PHST- 2002/04/27 10:00 [entrez]
AID - S019888590200383X [pii]
AID - 10.1016/s0198-8859(02)00383-x [doi]
PST - ppublish
SO  - Hum Immunol. 2002 May;63(5):424-33. doi: 10.1016/s0198-8859(02)00383-x.