PMID- 11979391
OWN - NLM
STAT- MEDLINE
DCOM- 20020606
LR  - 20190725
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 51
IP  - 5
DP  - 2002 May
TI  - Metabolic responses in a model of insulin resistance: comparison between oral 
      glucose and meal tolerance tests.
PG  - 595-8
AB  - The purpose of this investigation was to compare the benefits of a meal tolerance 
      test (MTT) against those of an oral glucose tolerance test (OGTT) in one of the 
      most commonly used models of insulin resistance, the Zucker fatty rat. Comparison 
      of these two oral challenges will facilitate determination of the most effective 
      means of inducing both glucose and insulin responses in this particular model and 
      allow for possible therapeutic benefits to be examined more effectively. 
      Eight-week-old Zucker fatty rats (n = 7 or 8) were used to perform either an OGTT 
      or a MTT following an overnight fast. The OGTT contained a final amount of 
      carbohydrate (CHO) of 1.2 g/kg body weight (BW). The MTT (commercially available 
      liquid meal), in addition to having fat and protein, included a final amount of 
      available CHO and volume to match the OGTT. A saline-treated group served as 
      control. A greater glucose excursion was observed following the OGTT compared to 
      the MTT. The maximal change in glucose from baseline was 140 +/- 10 mg/dL (a 
      2.1-fold rise) for the OGTT compared to 86.3 +/- 6.1 mg/dL (a 1.7-fold rise) for 
      the MTT (P <.05). The MTT induced a greater change from baseline in insulin 
      response compared to the OGTT (7.5 +/- 1.1 v 3.9 +/- 0.5 ng/mL, MTT v OGTT, 
      respectively; P <.05). The saline challenge induced only minimal glucose and 
      insulin responses in comparison to the other treatments. These results suggest 
      that, in a model of insulin resistance, the MTT is a more potent insulin 
      stimulator than glucose alone. A mixed meal, such as a MTT, provides a complete 
      nutrient challenge (CHO, fat, and protein) that will induce both glucose and 
      insulin responses, enabling a better capacity to detect differences in one of the 
      most often used models of insulin resistance, the Zucker fatty rat.
CI  - Copyright 2002, Elsevier Science (USA). All rights reserved.
FAU - Berthiaume, Nathalie
AU  - Berthiaume N
AD  - Global Pharmaceutical Research Division, Metabolic Disease Research, Abbott 
      Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-3500, USA.
FAU - Zinker, Bradley A
AU  - Zinker BA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Proteins)
RN  - 0 (Insulin)
SB  - IM
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Dietary Carbohydrates/administration & dosage
MH  - Dietary Fats/administration & dosage
MH  - Dietary Proteins/administration & dosage
MH  - Fasting
MH  - *Food
MH  - *Glucose Tolerance Test
MH  - Insulin/blood
MH  - *Insulin Resistance
MH  - Kinetics
MH  - Obesity/blood
MH  - Rats
MH  - Rats, Zucker
EDAT- 2002/04/30 10:00
MHDA- 2002/06/12 10:01
CRDT- 2002/04/30 10:00
PHST- 2002/04/30 10:00 [pubmed]
PHST- 2002/06/12 10:01 [medline]
PHST- 2002/04/30 10:00 [entrez]
AID - S0026049502576332 [pii]
AID - 10.1053/meta.2002.31989 [doi]
PST - ppublish
SO  - Metabolism. 2002 May;51(5):595-8. doi: 10.1053/meta.2002.31989.