PMID- 11979421
OWN - NLM
STAT- MEDLINE
DCOM- 20021003
LR  - 20161124
IS  - 1095-6670 (Print)
IS  - 1095-6670 (Linking)
VI  - 16
IP  - 2
DP  - 2002
TI  - TCDD-mediated oxidative stress in male rat pups following perinatal exposure.
PG  - 49-52
AB  - 2,3,7,8-tetrachlorododibenzo-p-dioxin (TCDD) is a highly persistent trace 
      environmental contaminant and is one of the most potent toxicants known. Exposure 
      to TCDD has been shown to cause oxidative stress in a variety of animal models. 
      In this study, pregnant Long Evans rats were dosed with 1 microg TCDD/kg on 
      gestational day (GD) 15 so as to investigate oxidative stress in the liver of 
      male pups following gestational exposure to TCDD. Lipid peroxidation (TBARS), 
      production of reactive oxygen species (ROS), and total glutathione (GSH) were 
      assayed to identify changes in oxidative stress parameters in the pup liver at GD 
      21 and postnatal days (PND) 4, 25, 32, 49, and 63. Mean ROS levels in pups were 
      elevated at all time points tested with a significant elevation at PND 4 and PND 
      25. However, pup hepatic lipid peroxidation was unchanged throughout the time 
      course. In addition, hepatic total GSH levels were not significantly changed 
      although the means for the TCDD-treated groups were less than those of the 
      controls at all time points except PND 49. The results indicate that although the 
      levels of ROS are increased following gestational/lactational exposure, this 
      increase does not translate to direct oxidative damage or significant changes to 
      endogenous antioxidant defense mechanisms. Further investigation into the effect 
      of gestational/lactational exposure in pups should include additional endpoints 
      for further characterization of the time course of the response, the effect upon 
      extrahepatic tissues, and investigation of differences between male and female 
      offspring.
CI  - Copyright 2002 Wiley Periodicals, Inc.
FAU - Slezak, B P
AU  - Slezak BP
AD  - Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel 
      Hill, NC, USA.
FAU - Hamm, J T
AU  - Hamm JT
FAU - Reyna, J
AU  - Reyna J
FAU - Hurst, C H
AU  - Hurst CH
FAU - Birnbaum, L S
AU  - Birnbaum LS
LA  - eng
GR  - ES07126/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biochem Mol Toxicol
JT  - Journal of biochemical and molecular toxicology
JID - 9717231
RN  - 0 (Environmental Pollutants)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Reactive Oxygen Species)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Cytochrome P-450 CYP1A1/metabolism
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Glutathione/metabolism
MH  - Lipid Peroxidation/drug effects
MH  - Liver/*drug effects/*metabolism
MH  - Male
MH  - Maternal Exposure
MH  - Microsomes, Liver/enzymology
MH  - Oxidative Stress/*drug effects
MH  - Polychlorinated Dibenzodioxins/*toxicity
MH  - Pregnancy
MH  - Rats
MH  - Rats, Long-Evans
MH  - Reactive Oxygen Species/analysis
EDAT- 2002/04/30 10:00
MHDA- 2002/10/04 04:00
CRDT- 2002/04/30 10:00
PHST- 2002/04/30 10:00 [pubmed]
PHST- 2002/10/04 04:00 [medline]
PHST- 2002/04/30 10:00 [entrez]
AID - 10.1002/jbt.10024 [doi]
PST - ppublish
SO  - J Biochem Mol Toxicol. 2002;16(2):49-52. doi: 10.1002/jbt.10024.