PMID- 11980710
OWN - NLM
STAT- MEDLINE
DCOM- 20020613
LR  - 20181113
IS  - 0261-4189 (Print)
IS  - 1460-2075 (Electronic)
IS  - 0261-4189 (Linking)
VI  - 21
IP  - 9
DP  - 2002 May 1
TI  - Tetrahedral aminopeptidase: a novel large protease complex from archaea.
PG  - 2132-8
AB  - A dodecameric protease complex with a tetrahedral shape (TET) was isolated from 
      Haloarcula marismortui, a salt-loving archaeon. The 42 kDa monomers in the 
      complex are homologous to metal-binding, bacterial aminopeptidases. TET has a 
      broad aminopeptidase activity and can process peptides of up to 30-35 amino acids 
      in length. TET has a central cavity that is accessible through four narrow 
      channels (<17 A wide) and through four wider channels (21 A wide). This 
      architecture is different from that of all the proteolytic complexes described to 
      date that are made up by rings or barrels with a single central channel and only 
      two openings.
FAU - Franzetti, B
AU  - Franzetti B
AD  - Institut de Biologie Structurale, UMR 5075 CEA-CNRS-UJF, 41 rue Jules Horowitz, 
      F-38027 Grenoble Cedex 1, France. franzetti@ibs.fr
FAU - Schoehn, G
AU  - Schoehn G
FAU - Hernandez, J-F
AU  - Hernandez JF
FAU - Jaquinod, M
AU  - Jaquinod M
FAU - Ruigrok, R W H
AU  - Ruigrok RW
FAU - Zaccai, G
AU  - Zaccai G
LA  - eng
PT  - Journal Article
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 0 (Archaeal Proteins)
RN  - 0 (Ion Channels)
RN  - 0 (Macromolecular Substances)
RN  - 0 (Protein Subunits)
RN  - EC 3.4.11.- (Aminopeptidases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Aminopeptidases/*chemistry/physiology
MH  - Archaeal Proteins/chemistry/physiology
MH  - Haloarcula marismortui/*chemistry/physiology
MH  - Ion Channels/chemistry/physiology/ultrastructure
MH  - Macromolecular Substances
MH  - Molecular Sequence Data
MH  - Protein Structure, Quaternary
MH  - Protein Subunits
MH  - Sequence Alignment
MH  - Substrate Specificity/physiology
PMC - PMC125989
EDAT- 2002/05/01 10:00
MHDA- 2002/06/14 10:01
PMCR- 2003/05/01
CRDT- 2002/05/01 10:00
PHST- 2002/05/01 10:00 [pubmed]
PHST- 2002/06/14 10:01 [medline]
PHST- 2002/05/01 10:00 [entrez]
PHST- 2003/05/01 00:00 [pmc-release]
AID - cdf220 [pii]
AID - 10.1093/emboj/21.9.2132 [doi]
PST - ppublish
SO  - EMBO J. 2002 May 1;21(9):2132-8. doi: 10.1093/emboj/21.9.2132.