PMID- 11981078
OWN - NLM
STAT- MEDLINE
DCOM- 20021008
LR  - 20190513
IS  - 0931-0509 (Print)
IS  - 0931-0509 (Linking)
VI  - 17
IP  - 5
DP  - 2002 May
TI  - Comparison of blood group versus HLA-dependent transplantation and its influence 
      on donor kidney survival.
PG  - 884-6
AB  - BACKGROUND: The advantages of organ allocation based on human leukocyte antigen 
      (HLA) typing are controversial. This evaluation compares the results of 
      HLA-dependent and non-HLA-dependent allocation in the transplantation of donor 
      kidneys. METHODS: Seventy-seven donor kidney pairs explanted locally between 1984 
      and 1994 were examined. One half of each pair was transplanted locally in Bonn on 
      the basis of criteria including blood group, waiting time and currently negative 
      cross-match. The other half of these pairs was allocated in accordance with the 
      Eurotransplant (ET) criteria. RESULTS: Cold ischaemia time was an average of 
      14.02 h in Bonn vs. 24.18 h in the ET group (P<0.0001). The number of HLA 
      mismatches was calculated and, for example, for locus A it was 1.13 in Bonn vs. 
      0.73 in the ET group (P=0.0003). One-year graft survival for the locally 
      transplanted kidneys was 92.2% and, for the ET kidneys, 90.9%. Five-year survival 
      was 79.5% vs. 81.7%, respectively. Patient survival after 1 year was 100% vs. 
      97.4%, and after 5 years, 93.4% vs. 93.1%. CONCLUSION: The results show that it 
      is possible to provide patients with a locally allocated kidney graft that 
      enables good function after a short waiting period. This procedure avoids long 
      cold ischaemia time and long waiting periods.
FAU - Gillich, Markus S
AU  - Gillich MS
AD  - Department of Urology, University of Bonn, Bonn, Germany. MGillich@t-online.de
FAU - Heimbach, Dirk
AU  - Heimbach D
FAU - Schoeneich, Georg
AU  - Schoeneich G
FAU - Muller, Stefan C
AU  - Muller SC
FAU - Klehr, Hans Ulrich
AU  - Klehr HU
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 0 (Blood Group Antigens)
RN  - 0 (HLA Antigens)
SB  - IM
CIN - Nephrol Dial Transplant. 2002 May;17(5):715-6. PMID: 11981052
CIN - Nephrol Dial Transplant. 2002 May;17(5):717-8. PMID: 11981053
MH  - Adult
MH  - *Blood Group Antigens
MH  - Female
MH  - Graft Survival
MH  - HLA Antigens/*analysis
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Kidney/*physiopathology
MH  - *Kidney Transplantation
MH  - Male
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Time Factors
EDAT- 2002/05/01 10:00
MHDA- 2002/10/09 04:00
CRDT- 2002/05/01 10:00
PHST- 2002/05/01 10:00 [pubmed]
PHST- 2002/10/09 04:00 [medline]
PHST- 2002/05/01 10:00 [entrez]
AID - 10.1093/ndt/17.5.884 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2002 May;17(5):884-6. doi: 10.1093/ndt/17.5.884.