PMID- 11981324
OWN - NLM
STAT- MEDLINE
DCOM- 20020912
LR  - 20190916
IS  - 1040-8711 (Print)
IS  - 1040-8711 (Linking)
VI  - 14
IP  - 3
DP  - 2002 May
TI  - Genetic approaches to the investigation of rheumatoid arthritis.
PG  - 260-9
AB  - The investigation of genetic factors affecting the development or severity of 
      rheumatoid arthritis may give new insights into the pathways involved in disease 
      pathogenesis and lead to the identification of novel therapeutic targets. 
      Recently, several novel approaches have been used in the attempt to unravel the 
      complex association of rheumatoid arthritis with the human leukocyte antigen ( 
      HLA ) gene region. It is clear that non-HLA genes are also involved in disease 
      pathogenesis, and identifying them remains a challenge. In the past year, 
      considerable headway has been made in this field, and some interesting strategies 
      have been used. This review summarizes the results of many of the HLA and non-HLA 
      studies and tries to draw lessons from the investigation of genetic 
      susceptibility factors in other complex diseases.
FAU - Barton, Anne
AU  - Barton A
AD  - ARC Epidemiology Unit, University of Manchester, Manchester, UK. 
      abarton@fs1.ser.man.ac.uk
FAU - Ollier, William
AU  - Ollier W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Rheumatol
JT  - Current opinion in rheumatology
JID - 9000851
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Arthritis, Rheumatoid/*genetics/physiopathology
MH  - Genetic Linkage
MH  - Genetic Predisposition to Disease/genetics
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Major Histocompatibility Complex/genetics
MH  - Severity of Illness Index
RF  - 97
EDAT- 2002/05/01 10:00
MHDA- 2002/09/13 10:01
CRDT- 2002/05/01 10:00
PHST- 2002/05/01 10:00 [pubmed]
PHST- 2002/09/13 10:01 [medline]
PHST- 2002/05/01 10:00 [entrez]
AID - 10.1097/00002281-200205000-00012 [doi]
PST - ppublish
SO  - Curr Opin Rheumatol. 2002 May;14(3):260-9. doi: 10.1097/00002281-200205000-00012.