PMID- 11981438
OWN - NLM
STAT- MEDLINE
DCOM- 20020521
LR  - 20190713
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 73
IP  - 8
DP  - 2002 Apr 27
TI  - Kidney transplantation in the elderly: age-matching as compared to HLA-matching: 
      a single center experience.
PG  - 1356-9
AB  - BACKGROUND: We report the short-term outcome of our patients participating within 
      the Eurotransplant age-matching program, where kidneys from donors >65 years are 
      transplanted to recipients >65 years regardless of human leukocyte antigen (HLA) 
      compatibility but with short cold ischemia times, in comparison with patients >60 
      years transplanted with HLA-matching. METHODS: Twenty-five patients (66.7+/-2.6 
      years) (donors 69+/-4.3 years) participated in this program (group A). The 
      control group consisted of 21 patients (63+/-2.6 years) (group B) (donors 
      47.6+/-17.3 years). RESULTS: Despite significant differences in donor age, cold 
      ischemia time (12.3+/-4.6 hr in A, 22.8+/-4.8 hr in B, P<0.001) and a mean of 
      4.4+/-1.4 vs. 2.3+/-1.6 HLA-mismatches (P<0.001), there was no difference 
      regarding the incidence of delayed graft function (64 vs. 57%), rejections (52 
      vs. 66.7%), infections (56 vs. 52.4%), and other complications (80 vs. 71.4%). 
      Mean serum creatinine after 6 months was 1.94+/-0.49 and 1.83+/-0.67 mg/dl (NS). 
      CONCLUSION: The short-term results of the age-matching program are promising and 
      comparable with results from patients of similar age with HLA-matching.
FAU - Voiculescu, Adina
AU  - Voiculescu A
AD  - Department of Nephrology and Rheumatology, Heinrich-Heine-University, Dusseldorf, 
      Germany.
FAU - Schlieper, Georg
AU  - Schlieper G
FAU - Hetzel, Gerd-Rudiger
AU  - Hetzel GR
FAU - Hollenbeck, Markus
AU  - Hollenbeck M
FAU - Ivens, Katrin
AU  - Ivens K
FAU - Willers, Reinhard
AU  - Willers R
FAU - Sandmann, Wilhelm
AU  - Sandmann W
FAU - Grabensee, Bernd
AU  - Grabensee B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - *Age Factors
MH  - Aged
MH  - Creatinine/blood
MH  - Graft Rejection/epidemiology
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Kidney Transplantation/immunology/*physiology
MH  - Middle Aged
MH  - Postoperative Complications/epidemiology
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2002/05/01 10:00
MHDA- 2002/05/22 10:01
CRDT- 2002/05/01 10:00
PHST- 2002/05/01 10:00 [pubmed]
PHST- 2002/05/22 10:01 [medline]
PHST- 2002/05/01 10:00 [entrez]
AID - 10.1097/00007890-200204270-00032 [doi]
PST - ppublish
SO  - Transplantation. 2002 Apr 27;73(8):1356-9. doi: 10.1097/00007890-200204270-00032.