PMID- 11981810
OWN - NLM
STAT- MEDLINE
DCOM- 20020614
LR  - 20180521
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 32
IP  - 5
DP  - 2002 May
TI  - Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting 
      chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human 
      CCX-CKR.
PG  - 1230-41
AB  - We report here the identification and characterization of murine CCX-CKR, a high 
      affinity receptor for the murine beta-chemokines SLC/mCCL21, MIP-3beta/mCCL19 and 
      TECK/mCCL25. Unlike most other chemokine receptors, CCX-CKR is unable to mediate 
      Ca(2+) fluxes upon ligand binding when expressed in HEK293 cells. Murine CCX-CKR 
      is expressed predominantly in the heart and lung, but is detectable in most 
      organs using RT-PCR. Interestingly, in brain and testis, an alternative mRNA form 
      of CCX-CKR exists with a unique 5' untranslated region (5'UTR) that overlaps with 
      a novel acyl-CoA dehydrogenase (ACD) gene. Analysis of human CCX-CKR shows that 
      the expression profiles and alternative 5'UTR are conserved. However, in man, 
      there are two copies of the CCX-CKR gene, one on chromosome 3 nestled within the 
      ACD homologue, and one on chromosome 6. These genes encode proteins with only one 
      amino acid difference, and their expression is independently regulated. This 
      study identifies murine CCX-CKR, reveals complex regulation of CCX-CKR gene 
      expression in mouse and man, and is suggestive of non-leukocytic targets for 
      MIP-3beta/CCL19, SLC/CCL21 and TECK/CCL25.
FAU - Townson, Jane R
AU  - Townson JR
AD  - The Beatson Institute for Cancer Research, Cancer Research UK Beatson 
      Laboratories, Glasgow, GB.
FAU - Nibbs, Robert J B
AU  - Nibbs RJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (5' Untranslated Regions)
RN  - 0 (CCL19 protein, human)
RN  - 0 (CCL21 protein, human)
RN  - 0 (CCL25 protein, human)
RN  - 0 (Ccl19 protein, mouse)
RN  - 0 (Ccl21c protein, mouse)
RN  - 0 (Ccl25 protein, mouse)
RN  - 0 (Chemokine CCL19)
RN  - 0 (Chemokine CCL21)
RN  - 0 (Chemokines, CC)
RN  - 0 (DNA, Complementary)
RN  - 0 (Ligands)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - 5' Untranslated Regions
MH  - Alternative Splicing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain/immunology/metabolism
MH  - Calcium Signaling
MH  - Cell Line
MH  - Chemokine CCL19
MH  - Chemokine CCL21
MH  - Chemokines, CC/*metabolism
MH  - Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - Gene Expression
MH  - Humans
MH  - Leukocytes/immunology/metabolism
MH  - Ligands
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - RNA, Messenger/genetics/metabolism
MH  - Receptors, Chemokine/genetics/*metabolism
MH  - Sequence Homology, Amino Acid
MH  - Species Specificity
MH  - Testis/immunology/metabolism
EDAT- 2002/05/01 10:00
MHDA- 2002/06/18 10:01
CRDT- 2002/05/01 10:00
PHST- 2002/05/01 10:00 [pubmed]
PHST- 2002/06/18 10:01 [medline]
PHST- 2002/05/01 10:00 [entrez]
AID - 10.1002/1521-4141(200205)32:5<1230::AID-IMMU1230>3.0.CO;2-L [doi]
PST - ppublish
SO  - Eur J Immunol. 2002 May;32(5):1230-41. doi: 
      10.1002/1521-4141(200205)32:5<1230::AID-IMMU1230>3.0.CO;2-L.