PMID- 11985790
OWN - NLM
STAT- MEDLINE
DCOM- 20050223
LR  - 20190513
IS  - 0910-5050 (Print)
IS  - 1876-4673 (Electronic)
IS  - 0910-5050 (Linking)
VI  - 93
IP  - 4
DP  - 2002 Apr
TI  - Association of HLA-DQB1*0301 and HLA-DQB1*0602 with different subtypes of gastric 
      cancer in Taiwan.
PG  - 404-10
AB  - Gastric cancer (GC) is a heterogeneous disorder with multifactorial etiologies. 
      Genetic predisposition, environmental factors, and Helicobacter pylori infection 
      are thought to interact in the manifestation of GC. Particular human leukocyte 
      antigen (HLA) alleles play a pivotal role in cellular immunity and may be an 
      important genetically determined host trait. To elucidate the association between 
      the genotype of HLA class II genes and the clinical phenotype of GC, 
      polymorphisms of HLA-DRB1 and HLA-DQB1 were determined by polymerase chain 
      reaction with sequence-specific primers in 106 Taiwanese patients with GC and in 
      208 healthy controls. Comparison of allele frequencies between GC patients and 
      healthy controls showed no significant difference at the HLA-DRB1 locus. Patients 
      with GC had a higher frequency of DQB1(*)0602 (9.4% vs. 3.6%, P < 0.05, odds 
      ratio 2.79, 95% confidence interval 1.41 - 5.47) and a lower frequency of 
      DQB1(*)0301 (14.6% vs. 23.8%, P < 0.05, odds ratio 0.55, 95% confidence interval 
      0.35 - 0.85) compared to healthy controls. Correlation of HLA-DQB1 status with 
      clinicopathologic features revealed predominance of male gender (16/3 vs. 50/37, 
      P < 0.05) and proximal location (12/7 vs. 28/59, P < 0.05) in patients with 
      positive HLA-DBQ1(*)0602 compared to those with negative HLA-DBQ1(*)0602. In 
      contrast, a higher ratio of diffuse/intestinal subtype (20/10 vs. 30/46, P < 
      0.05) and a lower seropositivity of Helicobacter pylori (14/30 vs. 58/76, P < 
      0.005) were noted in patients with positive HLA-DQB1(*)0301 compared to those 
      with negative HLA-DQB1(*)0301. In conclusion, HLA-DQB1(*)0602 confers 
      susceptibility to gastric cancer, especially for male Taiwanese and proximal 
      tumor location, while HLA-DQB1(*)0301 may have a protective effect on GC, 
      probably through resistance to Helicobacter pylori infection. HLA-DQB1 alleles 
      are associated with susceptibility or resistance to GC and also influence its 
      clinical features.
FAU - Wu, Ming-Shiang
AU  - Wu MS
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei, 
      Taiwan.
FAU - Hsieh, Rhong-Phong
AU  - Hsieh RP
FAU - Huang, Shih-Pei
AU  - Huang SP
FAU - Chang, Yu-Ting
AU  - Chang YT
FAU - Lin, Ming-Tsan
AU  - Lin MT
FAU - Chang, Ming-Chu
AU  - Chang MC
FAU - Shun, Chia-Tung
AU  - Shun CT
FAU - Sheu, Jin-Chuan
AU  - Sheu JC
FAU - Lin, Jaw-Town
AU  - Lin JT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Cancer Res
JT  - Japanese journal of cancer research : Gann
JID - 8509412
RN  - 0 (DNA Primers)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Oligonucleotides)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Case-Control Studies
MH  - DNA/genetics
MH  - DNA Primers/chemistry
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics/*immunology
MH  - HLA-DQ beta-Chains
MH  - Helicobacter pylori/metabolism
MH  - Humans
MH  - Immunoglobulin G/chemistry
MH  - Male
MH  - Membrane Glycoproteins/*genetics/*immunology
MH  - Middle Aged
MH  - Odds Ratio
MH  - Oligonucleotides/chemistry
MH  - Phenotype
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
MH  - Stomach Neoplasms/*genetics/*immunology
MH  - Taiwan
PMC - PMC5927011
EDAT- 2002/05/03 10:00
MHDA- 2005/02/24 09:00
PMCR- 2002/04/01
CRDT- 2002/05/03 10:00
PHST- 2002/05/03 10:00 [pubmed]
PHST- 2005/02/24 09:00 [medline]
PHST- 2002/05/03 10:00 [entrez]
PHST- 2002/04/01 00:00 [pmc-release]
AID - CAE404 [pii]
AID - 10.1111/j.1349-7006.2002.tb01271.x [doi]
PST - ppublish
SO  - Jpn J Cancer Res. 2002 Apr;93(4):404-10. doi: 10.1111/j.1349-7006.2002.tb01271.x.