PMID- 11990701
OWN - NLM
STAT- MEDLINE
DCOM- 20020604
LR  - 20190916
IS  - 1077-4114 (Print)
IS  - 1077-4114 (Linking)
VI  - 24
IP  - 2
DP  - 2002 Feb
TI  - Human herpesvirus 6 infection mimicking juvenile myelomonocytic leukemia in an 
      infant.
PG  - 136-41
AB  - In vitro cell culture studies of bone marrow and peripheral blood progenitor 
      cells from patients with juvenile myclomonocytic leukemia (JMML) consistently 
      show spontaneous proliferation and selective hypersensitivity to 
      granulocyte-macrophage colony-stimulating factor (GM-CSF). This GM-CSF 
      hypersensitivity dose-response assay has become a component of the international 
      diagnostic criteria for JMML. The authors report a 2-week-old boy with perinatal 
      human herpesvirus 6 (HHV-6) infection in whom in vitro bone marrow culture 
      studies suggested the diagnosis of JMML by showing increased spontaneous 
      proliferation, inhibition of this growth by anti-GM-CSF antibodies, and 
      hypersensitivity to GM-CSF. Polymerase chain reaction viral studies from whole 
      blood DNA and the shell vial viral culture assay were both positive for HHV-6. 
      The patient's condition improved with expectant treatment, with an eventual 
      return to normal blood counts and resolution of hepatosplenomegaly. This case of 
      perinatal HHV-6 infection shows that viruses can initially mimic the in vitro 
      culture results found in patients with JMML. It also illustrates that patients 
      suspected of having JMML should be observed if there are no signs of progressive 
      disease and concurrent features suggestive of viral infection.
FAU - Lorenzana, Adonis
AU  - Lorenzana A
AD  - Department of Pediatrics, St. John Hospital, Detroit, Michigan 48236, USA. 
      adonis.lorenzana@stjohn.org
FAU - Lyons, Hernando
AU  - Lyons H
FAU - Sawaf, Hadi
AU  - Sawaf H
FAU - Higgins, Martha
AU  - Higgins M
FAU - Carrigan, Donald
AU  - Carrigan D
FAU - Emanuel, Peter D
AU  - Emanuel PD
LA  - eng
GR  - CA60407/CA/NCI NIH HHS/United States
GR  - CA80916/CA/NCI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Pediatr Hematol Oncol
JT  - Journal of pediatric hematology/oncology
JID - 9505928
RN  - 0 (DNA, Viral)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Acute Kidney Injury/etiology
MH  - Bone Marrow/pathology
MH  - Bone Marrow Cells/drug effects
MH  - Cells, Cultured/drug effects
MH  - Colony-Forming Units Assay
MH  - DNA, Viral/blood
MH  - Diagnosis, Differential
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/antagonists & 
      inhibitors/pharmacology
MH  - Herpesvirus 6, Human/growth & development/*isolation & purification
MH  - Humans
MH  - Infant, Newborn
MH  - Jaundice, Neonatal/complications
MH  - Leukemia, Myelomonocytic, Acute/*diagnosis
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Roseolovirus Infections/complications/*diagnosis
MH  - Virus Cultivation
EDAT- 2002/05/07 10:00
MHDA- 2002/06/05 10:01
CRDT- 2002/05/07 10:00
PHST- 2002/05/07 10:00 [pubmed]
PHST- 2002/06/05 10:01 [medline]
PHST- 2002/05/07 10:00 [entrez]
AID - 10.1097/00043426-200202000-00016 [doi]
PST - ppublish
SO  - J Pediatr Hematol Oncol. 2002 Feb;24(2):136-41. doi: 
      10.1097/00043426-200202000-00016.