PMID- 11991303
OWN - NLM
STAT- MEDLINE
DCOM- 20020910
LR  - 20190822
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 57
IP  - 1
DP  - 2002 Jan
TI  - Immunoglobulin G antibodies to moulds in school-children from moisture problem 
      schools.
PG  - 9-16
AB  - BACKGROUND: The purpose of the present study was to evaluate mould-specific 
      immunoglobulin G (IgG) antibodies in children exposed to moisture and mould 
      problems in their school, and the association between IgG antibodies and mould 
      allergy, active or passive smoking and respiratory symptoms. METHODS: IgG 
      antibodies were studied to 24 moulds in 93 children from three moisture problem 
      schools and in 33 children from a reference school. The antibodies were measured 
      by enzyme-linked immunosorbent assay and compared to positive adult sera. 
      RESULTS: There were no significant differences in mould-specific IgG 
      concentrations between exposed and non-exposed school-children. Antibodies to 
      moulds common in moisture damaged buildings were associated with allergic 
      diseases, as well as with mould-specific immunoglobulin E (IgE) or skin prick 
      test (SPT) findings. Aspergillus fumigatus and A. versicolor were the moulds with 
      the most consistent findings. Active and passive smoking were associated with low 
      levels of antibodies to many moulds. Though the association between asthma, 
      wheezing or cough symptoms, and IgG to moulds was not significant, 7 (39%) of the 
      18 children with multiple (> 7) elevated IgG findings suffered from asthma or 
      wheezing. CONCLUSIONS: Allergy was, but asthma was not, associated with IgG 
      antibodies to the moulds that can be found in moisture damaged buildings. 
      However, no association was found between IgG antibodies to moulds and exposure 
      to moisture and moulds in school.
FAU - Taskinen, T M
AU  - Taskinen TM
AD  - Kiuruvesi Health Center, Kuopio, Finland.
FAU - Laitinen, S
AU  - Laitinen S
FAU - Nevalainen, A
AU  - Nevalainen A
FAU - Vepsalainen, A
AU  - Vepsalainen A
FAU - Meklin, T
AU  - Meklin T
FAU - Reiman, M
AU  - Reiman M
FAU - Korppi, M
AU  - Korppi M
FAU - Husman, T
AU  - Husman T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Antibodies, Fungal)
SB  - IM
MH  - Adolescent
MH  - Air Pollution, Indoor
MH  - Antibodies, Fungal/*blood
MH  - Asthma/epidemiology/immunology/microbiology
MH  - Child
MH  - Environmental Exposure
MH  - Female
MH  - Fungi/*immunology
MH  - Humans
MH  - Humidity/*adverse effects
MH  - Male
MH  - Mycoses/epidemiology/immunology/microbiology
MH  - Respiratory Hypersensitivity/epidemiology/immunology/microbiology
MH  - *Schools
MH  - Skin Tests
EDAT- 2002/05/07 10:00
MHDA- 2002/09/11 10:01
CRDT- 2002/05/07 10:00
PHST- 2002/05/07 10:00 [pubmed]
PHST- 2002/09/11 10:01 [medline]
PHST- 2002/05/07 10:00 [entrez]
AID - 10.1034/j.1398-9995.2002.13154.x [doi]
PST - ppublish
SO  - Allergy. 2002 Jan;57(1):9-16. doi: 10.1034/j.1398-9995.2002.13154.x.