PMID- 11992117
OWN - NLM
STAT- MEDLINE
DCOM- 20020619
LR  - 20220331
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 5
IP  - 6
DP  - 2002 Jun
TI  - A rapid switch in sympathetic neurotransmitter release properties mediated by the 
      p75 receptor.
PG  - 539-45
AB  - Cardiac function is modulated by norepinephrine release from innervating 
      sympathetic neurons. These neurons also form excitatory connections onto cardiac 
      myocytes in culture. Here we report that brain-derived neurotrophic factor (BDNF) 
      altered the neurotransmitter release properties of these sympathetic 
      neuron-myocyte connections in rodent cell culture, leading to a rapid shift from 
      excitatory to inhibitory cholinergic transmission in response to neuronal 
      stimulation. Fifteen minutes of BDNF perfusion was sufficient to cause this shift 
      to inhibitory transmission, indicating that BDNF promotes preferential release of 
      acetylcholine in response to neuronal stimulation. We found that p75(-/-) neurons 
      did not release acetylcholine in response to BDNF and that neurons overexpressing 
      p75 showed increased cholinergic transmission, indicating that the actions of 
      BDNF are mediated through the p75 neurotrophin receptor. Our findings indicate 
      that p75 is involved in modulating the release of distinct neurotransmitter 
      pools, resulting in a functional switch between excitatory and inhibitory 
      neurotransmission in individual neurons.
FAU - Yang, Bo
AU  - Yang B
AD  - Department of Biology, Volen Center for Complex Systems, 415 South St., M/S 008, 
      Brandeis University, Waltham, Massachusetts 02454, USA.
FAU - Slonimsky, John D
AU  - Slonimsky JD
FAU - Birren, Susan J
AU  - Birren SJ
LA  - eng
GR  - R01 NS40168/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Receptor, Nerve Growth Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
CIN - Nat Neurosci. 2002 Jun;5(6):503-4. PMID: 12037514
MH  - Acetylcholine/metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/pharmacology
MH  - Cell Communication/physiology
MH  - Cells, Cultured
MH  - Cholinergic Fibers/drug effects/physiology
MH  - Coculture Techniques
MH  - Mice
MH  - Mice, Knockout/genetics
MH  - Myocardium/cytology
MH  - Neurons/metabolism/physiology
MH  - Neurotransmitter Agents/*metabolism
MH  - Presynaptic Terminals/drug effects
MH  - Rats
MH  - Receptor, Nerve Growth Factor
MH  - Receptors, Nerve Growth Factor/genetics/*physiology
MH  - Sympathetic Nervous System/cytology/*metabolism
MH  - Synaptic Transmission/drug effects/physiology
MH  - Time Factors
EDAT- 2002/05/07 10:00
MHDA- 2002/06/20 10:01
CRDT- 2002/05/07 10:00
PHST- 2002/05/07 10:00 [pubmed]
PHST- 2002/06/20 10:01 [medline]
PHST- 2002/05/07 10:00 [entrez]
AID - nn853 [pii]
AID - 10.1038/nn0602-853 [doi]
PST - ppublish
SO  - Nat Neurosci. 2002 Jun;5(6):539-45. doi: 10.1038/nn0602-853.