PMID- 11997069
OWN - NLM
STAT- MEDLINE
DCOM- 20020703
LR  - 20190724
IS  - 0022-510X (Print)
IS  - 0022-510X (Linking)
VI  - 197
IP  - 1-2
DP  - 2002 May 15
TI  - Serum cytokine levels in Bell's palsy.
PG  - 69-72
AB  - OBJECTIVE: To assess the significance of the serum levels of the cytokines 
      (interleukine (IL-6, IL-8, IL-1b, IL-2r, and tumor necrosis factor alpha (TNF - 
      alpha)) in the patients with Bell's palsy. STUDY DESIGN: A clinical and 
      laboratory study in which serum cytokine levels were compared between the 
      patients who had Bell's palsy and healthy controls. METHODS: Twenty-three 
      patients with Bell's palsy and 30 healthy volunteers were included in the study. 
      The blood samples of the patients and controls were obtained, and serum IL-1b, 
      IL-2r, IL-6, IL-8, and TNF- alpha levels determined with chemiluminescence enzyme 
      immunometric assay on an Immulite Immunoassay. The serum of the patients was 
      taken between 2 days and 1 month after the disease. The assay was not in vitro 
      lymphocyte stimulation. RESULTS: The IL-6, IL-8 and TNF- alpha levels were 
      significantly higher in Bell's palsy than in controls (p < 0.05). The IL-1b and 
      IL-2r levels were similar in both groups (p > 0.05). The levels of cytokine IL-6, 
      IL-8, TNF- alpha, IL-1b, IL-2r did not correlate with the degree of recovery (p > 
      0.05). CONCLUSION: An alteration in the concentration of the cytokines is 
      expected not only in many inflammatory and infectious diseases but also in Bell's 
      palsy. Cytokines are not stored or preformed within cells. Therefore, high 
      cytokine levels (IL-6 and IL-8, and TNF- alpha) should represent their production 
      in response to underlying pathology in Bell's palsy, or these cytokines may be 
      pathogenetic factors in Bell's palsy. However, serum levels of these cytokines do 
      not help determine the prognosis in Bell's palsy as far as the results of this 
      study are concerned.
FAU - Yilmaz, Mustafa
AU  - Yilmaz M
AD  - Department of Neurology, Faculty of Medicine, Gaziantep University, Gaziantep, 
      Turkey.
FAU - Tarakcioglu, Mehmet
AU  - Tarakcioglu M
FAU - Bayazit, Nurhayat
AU  - Bayazit N
FAU - Bayazit, Yildirim A
AU  - Bayazit YA
FAU - Namiduru, Mustafa
AU  - Namiduru M
FAU - Kanlikama, Muzaffer
AU  - Kanlikama M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Receptors, Interleukin-2)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bell Palsy/blood/*immunology
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Interleukin-1/blood
MH  - Interleukin-6/blood
MH  - Interleukin-8/blood
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Receptors, Interleukin-2/blood
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 2002/05/09 10:00
MHDA- 2002/07/04 10:01
CRDT- 2002/05/09 10:00
PHST- 2002/05/09 10:00 [pubmed]
PHST- 2002/07/04 10:01 [medline]
PHST- 2002/05/09 10:00 [entrez]
AID - S0022510X02000497 [pii]
AID - 10.1016/s0022-510x(02)00049-7 [doi]
PST - ppublish
SO  - J Neurol Sci. 2002 May 15;197(1-2):69-72. doi: 10.1016/s0022-510x(02)00049-7.