PMID- 11999660 OWN - NLM STAT- MEDLINE DCOM- 20020904 LR - 20190819 IS - 1346-9843 (Print) IS - 1346-9843 (Linking) VI - 66 IP - 1 DP - 2002 Jan TI - Increased expression of monocyte chemoattractant protein-1 in atherectomy specimens from patients with restenosis after percutaneous transluminal coronary angioplasty. PG - 114-6 AB - The plasma concentration of monocyte chemoattractant protein-1 (MCP-1) antigen is higher in patients with restenosis after coronary angioplasty than in those who do not restenose. In this study the MCP-1 expression of coronary atherectomy specimens was investigated by immunohistochemistry. Samples were obtained from 12 patients with restenosis and 15 with de novo lesions by directional coronary atherectomy. MCP-1 immunoreactivity was found in all patients in the restenosis group and in 8 of the de novo group. The frequency of macrophage expression was higher in the restenosis group than in de novo group. These results indicate that local expression of MCP-1 may be associated with the mechanisms of vascular remodeling after coronary angioplasty. FAU - Hokimoto, Seiji AU - Hokimoto S AD - Division of Cardiology, Kumamoto Central Hospital, Kumamoto City, Japan. seisan@momo.so-net.ne.jp FAU - Oike, Yuichi AU - Oike Y FAU - Saito, Taro AU - Saito T FAU - Kitaoka, Mitsuhiko AU - Kitaoka M FAU - Oshima, Shuichi AU - Oshima S FAU - Noda, Katsuo AU - Noda K FAU - Moriyama, Yasushi AU - Moriyama Y FAU - Ishibashi, Fumiyuki AU - Ishibashi F FAU - Ogawa, Hisao AU - Ogawa H LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Japan TA - Circ J JT - Circulation journal : official journal of the Japanese Circulation Society JID - 101137683 RN - 0 (Chemokine CCL2) SB - IM MH - Adult MH - Aged MH - *Angioplasty, Balloon, Coronary MH - Chemokine CCL2/*blood MH - Coronary Restenosis/*blood MH - Female MH - Humans MH - Male MH - Middle Aged EDAT- 2002/05/10 10:00 MHDA- 2002/09/06 10:01 CRDT- 2002/05/10 10:00 PHST- 2002/05/10 10:00 [pubmed] PHST- 2002/09/06 10:01 [medline] PHST- 2002/05/10 10:00 [entrez] AID - 10.1253/circj.66.114 [doi] PST - ppublish SO - Circ J. 2002 Jan;66(1):114-6. doi: 10.1253/circj.66.114.