PMID- 12000070
OWN - NLM
STAT- MEDLINE
DCOM- 20021023
LR  - 20200225
IS  - 0160-9289 (Print)
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Linking)
VI  - 25
IP  - 4
DP  - 2002 Apr
TI  - Monocyte chemoattractant protein-1 and coronary artery disease.
PG  - 143-7
AB  - The designation of atherosclerosis as a chronic inflammatory process represents 
      an exciting and logical paradigm shift for cardiologists. Monocyte 
      chemoattractant protein-1 (MCP-1) plays an important role in the recruitment and 
      activation of monocytes and thus in the development of atherosclerosis. Enhanced 
      MCP-1 expression has been detected in macrophages, endothelial cells, and 
      vascular smooth muscle cells in the atheromatous plaque. Activation of 
      macrophages by MCP-1 also appears to be involved in the vulnerability of the 
      plaque. Indeed, circulating MCP-1 levels are elevated in patients with acute 
      myocardial infarction and in those with unstable angina, but not in patients with 
      stable angina. Production of MCP-1 and macrophage accumulation are also observed 
      after coronary angioplasty or grafting, indicating that MCP-1 expression may be 
      related not only to instability of atheromatous plaques, but also to the 
      formation of restenotic lesions. The development of therapeutic drugs for 
      atherosclerosis targeted specially against MCP-1 may be useful in the prevention 
      of plaque formation and future myocardial infarction.
FAU - Ikeda, Uichi
AU  - Ikeda U
AD  - Division of Cardiovascular Medicine, Jichi Medical School, Tochigi, Japan. 
      uikeda@jichi.ac.jp
FAU - Matsui, Keiji
AU  - Matsui K
FAU - Murakami, Yoshiaki
AU  - Murakami Y
FAU - Shimada, Kazuyuki
AU  - Shimada K
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Angina, Unstable/blood
MH  - Animals
MH  - Arteriosclerosis/*blood/pathology/prevention & control
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*blood
MH  - Coronary Restenosis/blood
MH  - Humans
MH  - Macrophage Activation
MH  - Myocardial Infarction/blood
MH  - Neovascularization, Physiologic
PMC - PMC6654294
EDAT- 2002/05/10 10:00
MHDA- 2002/10/31 04:00
PMCR- 2006/12/05
CRDT- 2002/05/10 10:00
PHST- 2002/05/10 10:00 [pubmed]
PHST- 2002/10/31 04:00 [medline]
PHST- 2002/05/10 10:00 [entrez]
PHST- 2006/12/05 00:00 [pmc-release]
AID - CLC4960250403 [pii]
AID - 10.1002/clc.4960250403 [doi]
PST - ppublish
SO  - Clin Cardiol. 2002 Apr;25(4):143-7. doi: 10.1002/clc.4960250403.