PMID- 1200034
OWN - NLM
STAT- MEDLINE
DCOM- 19760209
LR  - 20190626
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 59
IP  - 5
DP  - 1975 Nov
TI  - Acute interstitial nephritis. A clinical and pathologic study based on renal 
      biopsies.
PG  - 614-28
AB  - To define interstitial nephritis without preselection bias, 25 consecutive renal 
      biopsy specimens from patients with tubular damage, interstitial damage and 
      interstitial inflammation were analyzed in detail. In four patients (all with 
      acute renal failure), tubulitis, and interstitial eosinophil and lymphocyte 
      infiltration were found, but no glomerular abnormalities. In four others, the 
      findings were similar but some glomerular abnormalities were noted. Two patients 
      had probable healed interstitial nephritis. The clinical presentation varied from 
      transient renal insufficincy to oliguric renal failure. Three of the patients 
      with glomerular abnormalities had significant proteinuria. When the 10 patients 
      with interstitial nephritis were compared with the other 15 serving as controls, 
      striking features in the former group were skin rash, eosinophilia, the absence 
      of hypertension and the frequency of administration of penicillin and its 
      analogs. Serum immunoglobulin E (IgE) levels were elevated in three of the 
      patients. The striking eosinophilia, interstitial eosinophil infiltration and 
      increased IgE levels suggest that allergen-reaginic complexes may be involved in 
      the pathogenesis of the lesion.
FAU - Ooi, B S
AU  - Ooi BS
FAU - Jao, W
AU  - Jao W
FAU - First, M R
AU  - First MR
FAU - Mancilla, R
AU  - Mancilla R
FAU - Pollak, V E
AU  - Pollak VE
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 0 (Immunoglobulins)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Immunoglobulins/analysis
MH  - Kidney/immunology/*pathology/ultrastructure
MH  - Kidney Glomerulus/pathology
MH  - Kidney Tubules/pathology
MH  - Male
MH  - Microscopy, Electron
MH  - Middle Aged
MH  - Nephritis, Interstitial/diagnosis/*pathology
EDAT- 1975/11/01 00:00
MHDA- 1975/11/01 00:01
CRDT- 1975/11/01 00:00
PHST- 1975/11/01 00:00 [pubmed]
PHST- 1975/11/01 00:01 [medline]
PHST- 1975/11/01 00:00 [entrez]
AID - 0002-9343(75)90223-5 [pii]
AID - 10.1016/0002-9343(75)90223-5 [doi]
PST - ppublish
SO  - Am J Med. 1975 Nov;59(5):614-28. doi: 10.1016/0002-9343(75)90223-5.