PMID- 12000480
OWN - NLM
STAT- MEDLINE
DCOM- 20021008
LR  - 20191105
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 13
IP  - 2
DP  - 2002 Apr
TI  - The relationship among markers of allergy, asthma, allergic rhinitis, and eczema 
      in Costa Rica.
PG  - 91-7
AB  - The association between allergy markers and asthma and allergic rhinitis is 
      stronger in countries with a Western lifestyle than in rural areas of Africa and 
      Asia. We examined the relationship among allergy markers, asthma, rhinitis, and 
      eczema in a case-control study of 198 schoolchildren, 10-13 years of age, living 
      in Costa Rica, a Latin American country. The geometric mean total serum 
      immunoglobulin E (IgE) level in subjects with and without asthma was 465.0 and 
      143.0 IU/ml, respectively (difference = 322 IU/ml, 95% CI = 141.8-616.1 IU/ml, p 
      < 0.001), and that in subjects with and without allergic rhinitis was 442.5 and 
      144.3 IU/ml, respectively (difference = 298.2 IU/ml, 95% CI = 125.7-581.0 IU/ml, 
      p < 0.001). After adjusting for age, gender, and skin test reactivity to 
      allergens, we found a linear relationship between serum total IgE level and the 
      log odds ratio (OR) of having asthma. In a multivariate analysis, there was a 
      linear relationship between skin test reactivity to allergens and the log OR of 
      having allergic rhinitis. The OR of having allergic rhinitis was almost three 
      times higher in children who had four positive skin tests than in non-reactors. 
      Skin test reactivity to greater than five aeroallergens was an independent 
      predictor of eczema in a multivariate analysis (OR = 3.1, 95% CI = 1.1-8.4). 
      Although the geometric mean total serum IgE levels of Costa Rican children with 
      either asthma or allergic rhinitis are higher than those of children with asthma 
      or allergic rhinitis in most industrialized countries, the relationship among 
      markers of allergy, asthma, rhinitis, and eczema in Costa Rica is similar to that 
      found in countries with a Western lifestyle and different from that found in 
      rural areas of Asia and Africa.
FAU - Celedon, Juan C
AU  - Celedon JC
AD  - Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, 
      Boston, Massachusetts 02115, USA. juan.celedon@channing.harvard.edu
FAU - Soto-Quiros, Manuel E
AU  - Soto-Quiros ME
FAU - Hanson, Lars A
AU  - Hanson LA
FAU - Weiss, Scott T
AU  - Weiss ST
LA  - eng
GR  - R37 HL066289/HL/NHLBI NIH HHS/United States
GR  - HL-07427/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*immunology
MH  - Asthma/*epidemiology/immunology
MH  - Child
MH  - Costa Rica/epidemiology
MH  - Eczema/*epidemiology/immunology
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*epidemiology/etiology/immunology
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Multivariate Analysis
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Rhinitis, Allergic, Perennial/*epidemiology/immunology
MH  - Skin Tests
EDAT- 2002/05/10 10:00
MHDA- 2002/10/09 04:00
CRDT- 2002/05/10 10:00
PHST- 2002/05/10 10:00 [pubmed]
PHST- 2002/10/09 04:00 [medline]
PHST- 2002/05/10 10:00 [entrez]
AID - pai0o083 [pii]
AID - 10.1034/j.1399-3038.2002.00083.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2002 Apr;13(2):91-7. doi: 
      10.1034/j.1399-3038.2002.00083.x.