PMID- 12000502
OWN - NLM
STAT- MEDLINE
DCOM- 20021115
LR  - 20191105
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 13
IP  - 1
DP  - 2002 Feb
TI  - Severe food-induced vasculitis in two children.
PG  - 68-71
AB  - Food-induced vasculitis seems to be rare and is considered by some as 
      controversial. The reported cases in the literature are few and mostly on adult 
      patients. Described in this report are two children with severe vasculitis caused 
      by specific foods. They were diagnosed at two separate allergy centers that have 
      a special interest in food allergies. Case 1 was an 8-year-old girl with a 
      9-month history of cutaneous vasculitis with large joints involvement. Case 2 was 
      a 23-month-old girl with an 8-month history of multiple hospitalizations for 
      recurrent acute severe cutaneous and mucous membrane vasculitis with large joints 
      involvement. In both patients, skin biopsy showed leucocytoclastic vasculitis. In 
      neither of the patients could the symptoms be attributed to drug intake, 
      infection, autoimmunity, or other systemic disease. Case 1 had a moderately 
      elevated serum total immunoglobulin E (IgE) level and strongly positive skin test 
      and radioallergosorbent test (RAST) to cow's milk and hen's egg, both of which 
      were proven to be the cause by elimination-challenge tests. Case 2 had a slightly 
      elevated serum total IgE level, but negative skin tests to foods, including 
      chocolate that was suspected by the mother. Avoidance of chocolate resulted in 
      remission, except following accidental ingestion of cocoa-containing products. 
      These findings support the few previous reports on food-induced vasculitis, an 
      entity that seems rare but may be more common than currently realized.
FAU - Businco, Luisa
AU  - Businco L
AD  - Allergy and Immunology Division, Department of Pediatrics, University of Rome, La 
      Sapienza, Italy.
FAU - Falconieri, Paola
AU  - Falconieri P
FAU - Bellioni-Businco, Barbara
AU  - Bellioni-Businco B
FAU - Bahna, Sami L
AU  - Bahna SL
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
SB  - IM
MH  - Child
MH  - Female
MH  - Food Hypersensitivity/*complications
MH  - Humans
MH  - Infant
MH  - Vasculitis, Leukocytoclastic, Cutaneous/*etiology
EDAT- 2002/05/10 10:00
MHDA- 2002/11/26 04:00
CRDT- 2002/05/10 10:00
PHST- 2002/05/10 10:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/05/10 10:00 [entrez]
AID - pai0c097 [pii]
AID - 10.1034/j.1399-3038.2002.00097.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2002 Feb;13(1):68-71. doi: 
      10.1034/j.1399-3038.2002.00097.x.