PMID- 12001797
OWN - NLM
STAT- MEDLINE
DCOM- 20021113
LR  - 20161020
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 23
IP  - 2
DP  - 2002 Mar-Apr
TI  - Virus-provoked rhinitis in patients who have allergies.
PG  - 99-102
AB  - The most common illnesses in humans are the respiratory tract infections caused 
      by viruses. When limited to the upper respiratory region, these infections often 
      are designated as "a common cold." Viruses commonly associated with these upper 
      respiratory infections (URI) include rhinoviruses (RVs), respiratory syncytial 
      virus, influenza virus, parainfluenza virus, corona virus, and adenoviruses. 
      Clinical observations have suggested that patients with allergic rhinitis and 
      asthma experience more pronounced symptoms during a viral URI than patients who 
      do not have allergies and who are infected with the same virus under similar 
      circumstances. Using an experimental virus infection model in human volunteers 
      with and without allergic rhinitis, several groups of clinical investigators have 
      studied the effects of experimental RV infections. These observations indicate 
      that the experimental virus infection may induce host responses that provoke 
      enhanced immunoglobulin E (IgE) synthesis. Whether this translates into enhanced 
      symptoms has been suggested in one study but not in another. This article will 
      review these studies, which suggest that it is the host response to the virus and 
      not the virus itself that plays the major role in symptom pathogenesis.
FAU - Fireman, Philip
AU  - Fireman P
AD  - University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
SB  - IM
MH  - Humans
MH  - Respiratory Hypersensitivity/*complications/immunology/*virology
MH  - Rhinitis/*etiology/immunology/*virology
MH  - Rhinovirus/*pathogenicity
RF  - 13
EDAT- 2002/05/11 10:00
MHDA- 2002/11/26 04:00
CRDT- 2002/05/11 10:00
PHST- 2002/05/11 10:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/05/11 10:00 [entrez]
PST - ppublish
SO  - Allergy Asthma Proc. 2002 Mar-Apr;23(2):99-102.