PMID- 12001978
OWN - NLM
STAT- MEDLINE
DCOM- 20021029
LR  - 20190918
IS  - 1368-9800 (Print)
IS  - 1368-9800 (Linking)
VI  - 5
IP  - 1
DP  - 2002 Feb
TI  - Nutritional advice to increase soluble fibre intake does not change plasma folate 
      or homocysteine in men with angina: a randomised controlled trial.
PG  - 47-53
AB  - OBJECTIVE: To study the effect of advice to increase dietary soluble fibre, 
      including fruit and vegetables, on plasma folate and homocysteine in men with 
      angina. DESIGN: Data were collected on a subset of subjects from the Diet and 
      Angina Randomised Trial (DART II). In a randomised (2 x 2) factorial design, 
      subjects received advice on either, neither or both interventions to: (1) 
      increase soluble fibre intake to 8.0 g day(-1) (fruit, vegetables and oats); (2) 
      increase oily fish intake to 2 portions week(-1). Those who received soluble 
      fibre advice were compared with those who did not. Subjects were genotyped for 
      C677T variant 5,10-methylenetetrahydrofolate reductase (MTHFR). SETTING/SUBJECTS: 
      Seven hundred and fifty-three male angina patients were recruited from general 
      practice. RESULTS: Plasma homocysteine concentrations were at the upper end of 
      the normal range (median 11.5, 25% 9.4, 75% 14.0 micromol l(-1)). Baseline intake 
      of fruit and vegetables was positively correlated with plasma folate (r(s) = 
      0.29, P < 0.01). Smokers had lower intakes of fruit and vegetables, lower plasma 
      folate and higher homocysteine (all P < 0.01). Homozygotes for variant MTHFR had 
      higher homocysteine concentrations at low plasma folate (P < 0.01). Reported 
      intakes of fruit and vegetables and estimated dietary folate increased in the 
      intervention group (ca. +75 g day(-1), P < 0.01 and ca. +20 g day(-1), P < 0.05, 
      respectively). However, neither plasma folate (baseline/follow-up 4.5 vs. 4.4 
      microg l(-1), P = 0.40) nor homocysteine (baseline/follow-up 11.7 vs. 11.7 
      micromol l(-1), P = 0.31) changed. CONCLUSIONS: Plasma homocysteine, a 
      cardiovascular risk factor, is influenced by MTHFR genotype, plasma folate and 
      smoking status. Dietary advice successfully led to changes in fruit and vegetable 
      intake, but not to changes in plasma folate or homocysteine, possibly because the 
      fruits and vegetables that were chosen were not those richest in folate.
FAU - Ashfield-Watt, Pauline Al
AU  - Ashfield-Watt PA
AD  - Department of Medical Biochemistry and Centre for Applied Public Health Medicine, 
      Wales Heart Research Institute, University of Wales College of Medicine, Heath 
      Park, Cardiff, UK.
FAU - Clark, Zoe E
AU  - Clark ZE
FAU - Breay, Pat
AU  - Breay P
FAU - Zotos, Paul C
AU  - Zotos PC
FAU - Cale, Sara B
AU  - Cale SB
FAU - Burr, Michael L
AU  - Burr ML
FAU - McDowell, Ian F W
AU  - McDowell IF
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Public Health Nutr
JT  - Public health nutrition
JID - 9808463
RN  - 0 (Dietary Fiber)
RN  - 0 (Hematinics)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
RN  - EC 1.5.- (Oxidoreductases Acting on CH-NH Group Donors)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Aged
MH  - Angina Pectoris/blood/*diet therapy
MH  - Dietary Fiber/*administration & dosage
MH  - Folic Acid/*blood/drug effects/genetics
MH  - Fruit
MH  - Genotype
MH  - Hematinics/blood
MH  - Homocysteine/*blood
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)
MH  - Middle Aged
MH  - Oxidoreductases Acting on CH-NH Group Donors/genetics/metabolism
MH  - Risk Factors
MH  - Smoking/adverse effects
MH  - Solubility
MH  - Vegetables
EDAT- 2002/05/11 10:00
MHDA- 2002/10/31 04:00
CRDT- 2002/05/11 10:00
PHST- 2002/05/11 10:00 [pubmed]
PHST- 2002/10/31 04:00 [medline]
PHST- 2002/05/11 10:00 [entrez]
AID - S1368980002000071 [pii]
AID - 10.1079/PHN2001250 [doi]
PST - ppublish
SO  - Public Health Nutr. 2002 Feb;5(1):47-53. doi: 10.1079/PHN2001250.