PMID- 12002592
OWN - NLM
STAT- MEDLINE
DCOM- 20020802
LR  - 20131121
IS  - 0003-1488 (Print)
IS  - 0003-1488 (Linking)
VI  - 183
IP  - 9
DP  - 1983 Nov 1
TI  - Comparison of plasma aldosterone concentration among clinical status groups of 
      dogs with chronic heart failure.
PG  - 991-6
AB  - The plasma aldosterone concentration (PAC) among clinical status groups of 23 
      dogs with chronic heart failure was compared at various times after diagnosis of 
      the problem. Eighteen dogs admitted in New York Heart Association (NYHA) class IV 
      clinical status had significant elevations in PAC (P<0.0001), when compared with 
      clinically normal dogs. Five dogs admitted in NYHA class III status and 4 dogs 
      that responded with a change to NYHA class III status had significant elevations 
      in PAC (P<0.01), when compared with clinically normal dogs. In patients with NYHA 
      class IV status, the PAC was significantly greater (P<0.01) than in patients in 
      NYHA class III status. For patients with the poorest prognosis, ie, severe signs 
      of NYHA class IV status, the PAC was not markedly different, when compared with 
      that for patients with a favorable prognosis, ie, recent onset of signs of NYHA 
      class IV status. Patients treated with captopril had significantly lower PAC 
      after therapy (P<0.01), whereas patients treated with hydralazine had 
      significantly higher PAC (P<0.05) after therapy. It was concluded that heart 
      failure in the dog increases PAC, most likely because of 
      renin-angiotensin-aldosterone-system activation, and that the increase is related 
      directly to the clinical status of the patient. Further, it was concluded that 
      treatment of dogs in heart failure with captopril causes a decrease in 
      circulating PAC, whereas treatment with hydralazine causes an increase in 
      circulating PAC.
FAU - Knowlen, G G
AU  - Knowlen GG
AD  - Department of Small Animal Clinical Sciences, College of Veterinary Medicine, 
      Michigan State University, East Lansing 48824, USA.
FAU - Kittleson, M D
AU  - Kittleson MD
FAU - Nachreiner, R F
AU  - Nachreiner RF
FAU - Eyster, G E
AU  - Eyster GE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Vet Med Assoc
JT  - Journal of the American Veterinary Medical Association
JID - 7503067
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Antihypertensive Agents)
RN  - 26NAK24LS8 (Hydralazine)
RN  - 4964P6T9RB (Aldosterone)
RN  - 9G64RSX1XD (Captopril)
SB  - IM
MH  - Aldosterone/*blood
MH  - Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
MH  - Animals
MH  - Antihypertensive Agents/*therapeutic use
MH  - Captopril/therapeutic use
MH  - Chronic Disease
MH  - Dog Diseases/*blood/drug therapy
MH  - Dogs
MH  - Female
MH  - Heart Diseases/blood/drug therapy/*veterinary
MH  - Hydralazine/therapeutic use
MH  - Male
MH  - Prognosis
EDAT- 1983/11/01 00:00
MHDA- 2002/08/03 10:01
CRDT- 1983/11/01 00:00
PHST- 1983/11/01 00:00 [pubmed]
PHST- 2002/08/03 10:01 [medline]
PHST- 1983/11/01 00:00 [entrez]
PST - ppublish
SO  - J Am Vet Med Assoc. 1983 Nov 1;183(9):991-6.