PMID- 12006472
OWN - NLM
STAT- MEDLINE
DCOM- 20020611
LR  - 20201208
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 121
IP  - 5
DP  - 2002 May
TI  - Common features in the onset of ARDS after administration of granulocyte 
      colony-stimulating factor.
PG  - 1716-20
AB  - STUDY OBJECTIVE: Respiratory disturbance caused by ARDS has been reported during 
      administration of granulocyte-colony stimulating factor. The clinical features of 
      such respiratory distress were investigated in this study. DESIGN: Retrospective 
      case review. SETTING: A 1,100-bed university teaching hospital. PATIENTS: Five 
      patients who had dyspnea caused by ARDS develop after chemotherapy or bone marrow 
      transplantation (BMT) at our hospital. INTERVENTIONS: None. MEASUREMENTS AND 
      RESULTS: Levels of cytokines, human leukocyte antigen (HLA) typing, and the 
      clinical course were analyzed to clarify common features. All five patients 
      possessed HLA-B51 or HLA-B52, and all had fever and an enhanced inflammatory 
      response at the time of the WBC nadir. The tumor necrosis factor (TNF)-alpha and 
      interleukin (IL)-8 levels increased when respiratory distress syndrome occurred. 
      CONCLUSIONS: If patients with HLA-B51 or HLA-B52 have infection develop at the 
      time of WBC nadir after chemotherapy or BMT, ARDS may occur in association with 
      elevation of TNF-alpha and IL-8 during WBC recovery.
FAU - Takatsuka, Hiroyuki
AU  - Takatsuka H
AD  - Second Department of Internal Medicine, Hyogo College of Medicine, Nishinimiya, 
      Hyogo, Japan. hematol@hyo-med.ac.jp
FAU - Takemoto, Yoshinobu
AU  - Takemoto Y
FAU - Mori, Ako
AU  - Mori A
FAU - Okamoto, Takahiro
AU  - Okamoto T
FAU - Kanamaru, Akihisa
AU  - Kanamaru A
FAU - Kakishita, Eizo
AU  - Kakishita E
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
RN  - 0 (Antineoplastic Agents)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B51 Antigen)
RN  - 0 (HLA-B52 Antigen)
RN  - 0 (Interleukin-8)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
SB  - IM
CIN - Chest. 2002 May;121(5):1391-2. PMID: 12006416
MH  - Adult
MH  - Antineoplastic Agents/adverse effects
MH  - Bone Marrow Transplantation/adverse effects
MH  - Female
MH  - Granulocyte Colony-Stimulating Factor/*adverse effects
MH  - HLA-B Antigens/analysis
MH  - HLA-B51 Antigen
MH  - HLA-B52 Antigen
MH  - Humans
MH  - Interleukin-8/blood/physiology
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Recombinant Proteins
MH  - Respiratory Distress Syndrome/blood/*chemically induced/physiopathology
MH  - Retrospective Studies
MH  - Tumor Necrosis Factor-alpha/analysis/physiology
EDAT- 2002/05/15 10:00
MHDA- 2002/06/12 10:01
CRDT- 2002/05/15 10:00
PHST- 2002/05/15 10:00 [pubmed]
PHST- 2002/06/12 10:01 [medline]
PHST- 2002/05/15 10:00 [entrez]
AID - S0012-3692(15)34899-6 [pii]
AID - 10.1378/chest.121.5.1716 [doi]
PST - ppublish
SO  - Chest. 2002 May;121(5):1716-20. doi: 10.1378/chest.121.5.1716.