PMID- 12007134
OWN - NLM
STAT- MEDLINE
DCOM- 20030818
LR  - 20121115
IS  - 0173-0835 (Print)
IS  - 0173-0835 (Linking)
VI  - 23
IP  - 9
DP  - 2002 May
TI  - The use of a highly sulfated cyclodextrin for the simultaneous chiral separation 
      of amphetamine-type stimulants by capillary electrophoresis.
PG  - 1328-34
AB  - We investigated the simultaneous chiral separation of nine amphetamine type 
      stimulants (dl-norephedrine, dl-norpseudoephedrine, dl-ephedrine, 
      dl-pseudoephedrine, dl-amphetamine, dl-methamphetamine, 
      dl-methylenedioxyamphetamine (MDA), dl-methylenedioxymethamphetamine (MDMA), and 
      dl-methylenedioxyethylamphetamine (MDEA)) by capillary electrophoresis using 
      highly sulfated gamma-cyclodextrin (SU(XIII)-gamma-CD) as a chiral selector. 
      Three different approaches using SU(XIII)-gamma-CD with 50 mM phosphate 
      background electrolyte were designed; (I) high CD concentration (10 mM 
      SU(XIII)-gamma-CD) at neutral pH (pH 7.0) in the normal polarity mode, (II) low 
      CD concentration (1.0 mM) at low pH (pH 2.6) in the normal polarity mode and 
      (III) high CD concentration at low pH (pH 2.6) in the reversed-polarity mode. In 
      mode (II), the effects of adding three neutral CDs (beta-CD, dimethyl-beta-CD and 
      hydroxypropyl-beta-CD) were also investigated. The best separation was obtained 
      after optimizing mode (III) as follows: run buffer of 10 mM SU(XIII)-gamma-CD 
      with 50 mM phosphate background electrolyte at pH 2.6, applied voltage of -12 kV 
      and capillary temperature of 15 degrees C.
FAU - Iwata, Yuko T
AU  - Iwata YT
AD  - National Research Institute of Police Science, Chiba, Japan. togawa@nrips.go.jp
FAU - Garcia, Agnes
AU  - Garcia A
FAU - Kanamori, Tatsuyuki
AU  - Kanamori T
FAU - Inoue, Hiroyuki
AU  - Inoue H
FAU - Kishi, Tohru
AU  - Kishi T
FAU - Lurie, Ira S
AU  - Lurie IS
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Electrophoresis
JT  - Electrophoresis
JID - 8204476
RN  - 0 (Adrenergic Agents)
RN  - 0 (Amphetamines)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Cyclodextrins)
RN  - 0 (Sulfates)
RN  - 0 (gamma-Cyclodextrins)
RN  - KZJ0BYZ5VA (gamma-cyclodextrin)
SB  - IM
MH  - Adrenergic Agents/isolation & purification
MH  - Amphetamines/*isolation & purification
MH  - Central Nervous System Stimulants/*isolation & purification
MH  - Chromatography, Micellar Electrokinetic Capillary/*methods
MH  - Cyclodextrins/*chemistry/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Hydrogen-Ion Concentration
MH  - Osmolar Concentration
MH  - Stereoisomerism
MH  - Sulfates/chemistry/pharmacology
MH  - Temperature
MH  - *gamma-Cyclodextrins
EDAT- 2002/05/15 10:00
MHDA- 2003/08/19 05:00
CRDT- 2002/05/15 10:00
PHST- 2002/05/15 10:00 [pubmed]
PHST- 2003/08/19 05:00 [medline]
PHST- 2002/05/15 10:00 [entrez]
AID - 10.1002/1522-2683(200205)23:9<1328::AID-ELPS1328>3.0.CO;2-Z [doi]
PST - ppublish
SO  - Electrophoresis. 2002 May;23(9):1328-34. doi: 
      10.1002/1522-2683(200205)23:9<1328::AID-ELPS1328>3.0.CO;2-Z.