PMID- 12010603
OWN - NLM
STAT- MEDLINE
DCOM- 20020703
LR  - 20191106
IS  - 1523-3774 (Print)
IS  - 1523-3774 (Linking)
VI  - 4
IP  - 3
DP  - 2002 Jun
TI  - Genetics in rheumatoid arthritis.
PG  - 195-200
AB  - The data from the human genome project were published in 2001. Although this 
      achievement will boost research in the genetics of rheumatoid arthritis (RA), 
      most of the work is in progress. Three of the four consortia that are performing 
      linkage studies to identify loci that are transmitted more often to patients than 
      controls have published data on genome-wide searches in few families. Of all the 
      possible candidate genes, the human leukocyte antigen (HLA) class II region was 
      found in the pan-European and the US linkage studies, confirming the previous 
      data from association studies that HLA class II alleles confer risk to RA. 
      Although HLA as a risk factor for RA has been known for a long time, the 
      mechanism by which HLA alleles affect disease risk are controversial. Several 
      papers have been published recently that support the RA-protection hypothesis. 
      Several candidate loci/genes have been suggested from association studies. 
      However, these associations have not been reproduced by different groups in 
      several different cohorts.
FAU - Huizinga, Tom W J
AU  - Huizinga TW
AD  - Leiden University Medical Center, Department of Rheumatology, C4-R, PO Box 9600, 
      2300 RC Leiden, The Netherlands. T.W.J.Huizinga@lumc.nl
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Rheumatol Rep
JT  - Current rheumatology reports
JID - 100888970
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Arthritis, Rheumatoid/*genetics
MH  - Genetic Predisposition to Disease/genetics
MH  - HLA Antigens/genetics
MH  - Humans
RF  - 44
EDAT- 2002/05/16 10:00
MHDA- 2002/07/04 10:01
CRDT- 2002/05/16 10:00
PHST- 2002/05/16 10:00 [pubmed]
PHST- 2002/07/04 10:01 [medline]
PHST- 2002/05/16 10:00 [entrez]
AID - 10.1007/s11926-002-0065-2 [doi]
PST - ppublish
SO  - Curr Rheumatol Rep. 2002 Jun;4(3):195-200. doi: 10.1007/s11926-002-0065-2.