PMID- 12012078
OWN - NLM
STAT- MEDLINE
DCOM- 20030110
LR  - 20131121
IS  - 1439-6319 (Print)
IS  - 1439-6319 (Linking)
VI  - 87
IP  - 1
DP  - 2002 May
TI  - Effect of beta(1)-selective adrenergic blockade on maximal blood lactate steady 
      state in healthy men.
PG  - 66-71
AB  - The aim of this study was to compare the effect of taking bisoprolol (B), a 
      highly beta(1)-selective adrenoceptor antagonist to that of a placebo (P) on 
      maximal lactate steady state (MLSS), which reflects the transition from oxidative 
      to partially anaerobic metabolism. Ten healthy male subjects [mean (SD) age 23 
      (3) years, height 181 (6) cm, body mass 76 (6) kg] randomly received oral P or B 
      (5 mg x day(-1)) for 2 weeks using a double-blind crossover design. In the 2nd 
      week, the subjects performed an incremental cycle ergometer test until exhaustion 
      to determine the second blood lactate turn point (LTP(2)). At regular intervals 
      of 24-48 h, the subjects performed 2-3 steady-state tests to determine the MLSS. 
      During the incremental exercise, heart rate (HR) was significantly lower at rest 
      (15 beats x min(-1)), at LTP(2) (23 beats x min(-1)) and at maximal power output 
      (19 beats x min(-1)) when taking B compared to P. Oxygen pulse was significantly 
      higher taking B and no significant differences were observed for any of the 
      respiratory gas exchange measurements (RGEM) (oxygen consumption, carbon dioxide 
      production, minute ventilation, respiratory exchange ratio), exercise intensity 
      or blood lactate concentration (LA) at baseline, at LTP(2) and at maximal power 
      output. During exercise at constant intensity, significant differences between B 
      and P were found for HR [148 (12) compared to 176 (11) beats x min(-1)] and 
      oxygen pulse [21.8 (1.9) compared to 19.2 (1.6) ml] at MLSS. No difference was 
      found for exercise intensity [216 (18) compared to 218 (18) W], for RGEM, LA [5.3 
      (1.1) compared to 4.8 (1.5) mmol x l(-1)] and ratings of perceived exertion [18.1 
      (1.6) compared to 17.4 (1.7)] for B and P at MLSS. In both, the power output at 
      LTP(2) was slightly higher than power output at MLSS (within an intensity step). 
      Commonly measured cardiorespiratory and subjective variables determined during 
      treatment with 5 mg bisoprolol can be used for testing cardiorespiratory fitness 
      and for prescription of training intensity.
FAU - Wonisch, Manfred
AU  - Wonisch M
AD  - Department of Sport Science, Karl-Franzens-University, Graz, Austria.
FAU - Hofmann, Peter
AU  - Hofmann P
FAU - Fruhwald, Friedrich M
AU  - Fruhwald FM
FAU - Hoedl, Ronald
AU  - Hoedl R
FAU - Schwaberger, Gunther
AU  - Schwaberger G
FAU - Pokan, Rochus
AU  - Pokan R
FAU - von Duvillard, Serge P
AU  - von Duvillard SP
FAU - Klein, Werner
AU  - Klein W
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20020322
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 33X04XA5AT (Lactic Acid)
RN  - Y41JS2NL6U (Bisoprolol)
SB  - IM
MH  - Adrenergic beta-Antagonists/*administration & dosage
MH  - Adult
MH  - Anaerobic Threshold/drug effects
MH  - Bisoprolol/*administration & dosage
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - Humans
MH  - Lactic Acid/*blood
MH  - Male
MH  - Physical Exertion/*drug effects
EDAT- 2002/05/16 10:00
MHDA- 2003/01/11 04:00
CRDT- 2002/05/16 10:00
PHST- 2002/01/26 00:00 [accepted]
PHST- 2002/05/16 10:00 [pubmed]
PHST- 2003/01/11 04:00 [medline]
PHST- 2002/05/16 10:00 [entrez]
AID - 10.1007/s00421-002-0595-3 [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2002 May;87(1):66-71. doi: 10.1007/s00421-002-0595-3. Epub 
      2002 Mar 22.