PMID- 12013666
OWN - NLM
STAT- MEDLINE
DCOM- 20020603
LR  - 20190605
IS  - 0470-8105 (Print)
IS  - 0470-8105 (Linking)
VI  - 42
IP  - 4
DP  - 2002 Apr
TI  - Disturbed spatial learning of rats after intraventricular administration of 
      transforming growth factor-beta 1.
PG  - 151-6; discussion 157
AB  - Patients with subarachnoid hemorrhage (SAH) who later suffer hydrocephalus show 
      persistently high levels of transforming growth factor-beta 1 (TGF-beta 1) in the 
      cerebrospinal fluid after the onset of SAH. Recombinant TGF-beta 1 induces 
      hydrocephalus in mice. This study examined the spatial learning ability of rats 
      after intraventricular administration of TGF-beta 1. Thirteen-week-old Wistar 
      rats were treated with 0.8 or 8.0 micrograms of human recombinant TGF-beta 1 by 
      direct injection or via osmotic pump. Three months later, their spatial learning 
      ability was evaluated with a Morris water maze. Ventricular size, ultrastructural 
      features, and sodium-potassium-adenosine triphosphatase (Na+, K(+)-ATPase) 
      activity of the subarachnoid space were examined. All three TGF-beta 1-treated 
      groups clearly exhibited impaired spatial learning ability, but they did not 
      exhibit ventricular dilation. Histological examination revealed subarachnoid 
      fibrosis and deactivation of Na+, K(+)-ATPase in the arachnoid cells. These 
      findings are similar to those of our previous experiments involving injection of 
      TGF-beta 1 in mice. The present and previous studies suggest that subarachnoid 
      fibrosis is an important factor in the disturbance of the spatial learning 
      ability of rats, whereas ventricular size is less important.
FAU - Nakazato, Fumi
AU  - Nakazato F
AD  - Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, 
      Nagano. tadatsu@hsp.md.shinshu-u.ac.jp
FAU - Tada, Tsuyoshi
AU  - Tada T
FAU - Sekiguchi, Yasuyuki
AU  - Sekiguchi Y
FAU - Murakami, Kentaro
AU  - Murakami K
FAU - Yanagisawa, Shin
AU  - Yanagisawa S
FAU - Tanaka, Yuichiro
AU  - Tanaka Y
FAU - Hongo, Kazuhiro
AU  - Hongo K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Neurol Med Chir (Tokyo)
JT  - Neurologia medico-chirurgica
JID - 0400775
RN  - 0 (TGFB1 protein, human)
RN  - 0 (Tgfb1 protein, rat)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Animals
MH  - Injections, Intraventricular
MH  - Maze Learning/*drug effects
MH  - Rats
MH  - Transforming Growth Factor beta/*administration & dosage/pharmacology
MH  - Transforming Growth Factor beta1
EDAT- 2002/05/17 10:00
MHDA- 2002/06/04 10:01
CRDT- 2002/05/17 10:00
PHST- 2002/05/17 10:00 [pubmed]
PHST- 2002/06/04 10:01 [medline]
PHST- 2002/05/17 10:00 [entrez]
AID - JST.JSTAGE/nmc/42.151 [pii]
AID - 10.2176/nmc.42.151 [doi]
PST - ppublish
SO  - Neurol Med Chir (Tokyo). 2002 Apr;42(4):151-6; discussion 157. doi: 
      10.2176/nmc.42.151.