PMID- 12014622
OWN - NLM
STAT- MEDLINE
DCOM- 20020627
LR  - 20060422
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 22
IP  - 2A
DP  - 2002 Mar-Apr
TI  - Dendritic cells in human squamous cell carcinoma of the oral cavity.
PG  - 545-57
AB  - Dendritic cells (DCs) are antigen-presenting cells that initiate and modulate 
      immune responses, including tumor immunity. In this study we examined, 
      immunohistochemically, the distribution of DC subsets in the primary tumor, 
      adjacent tissue and regional lymph nodes (RLNs) of patients with oral squamous 
      cell carcinoma (OSCC). The numbers of S100+ and CD1a+ DCs in tissue adjacent to 
      the primary tumor were greater in patients without metastasis to RLNs (PN- 
      cases), compared with those with metastasis (PN+ cases), while greater numbers of 
      CD83+ DCs in the primary tumors were found in PN+ cases. In the RLNs, the numbers 
      of S100+ and CD1a+ DCs were less in PN+ cases than in PN- cases, while the 
      numbers of CD83+ DCs were greater in PN+ cases compared with those in PN- cases. 
      These results suggest that the distribution of DC subsets in OSCC may reflect the 
      degree of tumor immunity induced in the host bearing OSCC.
FAU - Kikuchi, Kentaro
AU  - Kikuchi K
AD  - 1st Department of Oral and Maxillofacial Surgery, Meikai University School of 
      Dentistry, Sakado, Saitama, Japan. kenta@cb3.so-net.ne.jp
FAU - Kusama, Kaoru
AU  - Kusama K
FAU - Taguchi, Kohei
AU  - Taguchi K
FAU - Ishikawa, Fumitaka
AU  - Ishikawa F
FAU - Okamoto, Motoyoshi
AU  - Okamoto M
FAU - Shimada, Jun
AU  - Shimada J
FAU - Sakashita, Hideaki
AU  - Sakashita H
FAU - Yamamo, Yoshiro
AU  - Yamamo Y
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, CD1)
RN  - 0 (CD1a antigen)
RN  - 0 (S100 Proteins)
RN  - 0 (S100A1 protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Monoclonal/metabolism
MH  - Antigens, CD1/immunology/metabolism
MH  - Carcinoma, Squamous Cell/*immunology/pathology
MH  - Dendritic Cells/immunology/*pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Lymph Nodes/immunology/pathology
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*immunology/pathology
MH  - Neoplasm Staging
MH  - S100 Proteins/immunology/metabolism
EDAT- 2002/05/17 10:00
MHDA- 2002/06/28 10:01
CRDT- 2002/05/17 10:00
PHST- 2002/05/17 10:00 [pubmed]
PHST- 2002/06/28 10:01 [medline]
PHST- 2002/05/17 10:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 2002 Mar-Apr;22(2A):545-57.