PMID- 12017219
OWN - NLM
STAT- MEDLINE
DCOM- 20021112
LR  - 20181217
IS  - 0334-018X (Print)
IS  - 0334-018X (Linking)
VI  - 15 Suppl 1
DP  - 2002 Apr
TI  - Genes with linkage or association with type 2 diabetes mellitus.
PG  - 471-84
AB  - Complex diseases, such as type 2 diabetes mellitus (T2DM), arise from metabolic 
      disruptions with genetic and environmental components. Multiple genes are 
      responsible for the genetic susceptibility to T2DM. The contribution of these 
      genes to the diabetic phenotype may be modest, variable among different 
      populations, and dependent on interactions with other genes and the environment. 
      The methods of genetic dissection based on linkage, allele sharing, and linkage 
      disequilibrium may lack the statistical power to detect weak associations in 
      heterogeneous populations. Nevertheless, genes involved in insulin signaling, 
      insulin secretion, insulin resistance, glucose metabolism, obesity, diabetes 
      comorbidity and the hormone processing protease genes have been associated with 
      T2DM. New research strategies are improving the methods of genetic dissection and 
      include genomic sequence information to characterize profiles of sequence 
      variants that predispose to T2DM.
FAU - Bastian, William
AU  - Bastian W
AD  - Department of Pediatrics, State University of New York Health Science Center at 
      Brooklyn, 11203, USA. wbastian@netmail.hscbklyn.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - J Pediatr Endocrinol Metab
JT  - Journal of pediatric endocrinology & metabolism : JPEM
JID - 9508900
RN  - 0 (Insulin)
RN  - EC 2.7.10.1 (Receptor, Insulin)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Chromosome Mapping
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Genetic Linkage
MH  - Glucose/metabolism
MH  - Humans
MH  - Insulin/metabolism
MH  - Insulin Resistance/genetics
MH  - Insulin Secretion
MH  - Receptor, Insulin/genetics
MH  - Signal Transduction/genetics
RF  - 127
EDAT- 2002/05/23 10:00
MHDA- 2002/11/26 04:00
CRDT- 2002/05/23 10:00
PHST- 2002/05/23 10:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/05/23 10:00 [entrez]
PST - ppublish
SO  - J Pediatr Endocrinol Metab. 2002 Apr;15 Suppl 1:471-84.