PMID- 12017338
OWN - NLM
STAT- MEDLINE
DCOM- 20020625
LR  - 20211203
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 22
IP  - 1A
DP  - 2002 Jan-Feb
TI  - Aberrant expression of cyclin A in laryngeal squamous cell carcinoma.
PG  - 83-9
AB  - The expression of cyclin A protein was retrospectively investigated in 102 
      patients with human laryngeal squamous cell carcinoma (LSCC) by using 
      immunohistochemistry. Out of 102 tumors, 41 (40.2%) exhibited positive-staining 
      in cancer cells with this antibody. No association between cyclin A 
      overexpression and the patients' clinicopathological parameters was found. 
      However, cyclin A overexpression was significantly associated with CDK2 and PCNA 
      expression (p = 0.01 and p = 0.001, respectively). Kaplan-Meier analysis showed 
      that patients with overexpression of cyclin A were associated with poor 
      disease-free survival (p = 0.046), but it was not associated with overall 
      survival (p = 0.106). Additionally, patients with both lymph node metastasis and 
      cyclin A overexpression were significantly associated with worse disease-free 
      survival (p < 0.0001). The multivariate analysis showed that tumor size, lymph 
      node metastasis and cyclin A overexpression are significantly independent 
      prognostic factors of disease-free survival. These findings suggest that cyclin A 
      overexpression is associated with recurrence of LSCC.
FAU - Dong, Youyi
AU  - Dong Y
AD  - Department of Physiology, Kagawa Medical University, Kita-gun, Japan.
FAU - Sui, Li
AU  - Sui L
FAU - Watanabe, Yasuo
AU  - Watanabe Y
FAU - Sugimoto, Katsuyoshi
AU  - Sugimoto K
FAU - Tokuda, Masaaki
AU  - Tokuda M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Cyclin A)
RN  - 0 (Proliferating Cell Nuclear Antigen)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.22 (CDC2-CDC28 Kinases)
RN  - EC 2.7.11.22 (CDK2 protein, human)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinase 2)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *CDC2-CDC28 Kinases
MH  - Carcinoma, Squamous Cell/*metabolism/mortality/pathology
MH  - Cell Division/physiology
MH  - Cyclin A/*biosynthesis
MH  - Cyclin-Dependent Kinase 2
MH  - Cyclin-Dependent Kinases/biosynthesis
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*metabolism/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Staging
MH  - Proliferating Cell Nuclear Antigen/metabolism
MH  - Protein Serine-Threonine Kinases/biosynthesis
MH  - Retrospective Studies
MH  - Survival Rate
EDAT- 2002/05/23 10:00
MHDA- 2002/06/26 10:01
CRDT- 2002/05/23 10:00
PHST- 2002/05/23 10:00 [pubmed]
PHST- 2002/06/26 10:01 [medline]
PHST- 2002/05/23 10:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 2002 Jan-Feb;22(1A):83-9.