PMID- 12020039
OWN - NLM
STAT- MEDLINE
DCOM- 20021106
LR  - 20161124
IS  - 1230-6002 (Print)
IS  - 1230-6002 (Linking)
VI  - 54
IP  - 1
DP  - 2002 Jan-Feb
TI  - Effect of (S)-3,5-DHPG on learning, exploratory activity and anxiety in rats with 
      experimental hypoxia.
PG  - 11-8
AB  - We investigated the effects of (S)-3,5-DHPG, a selective agonist of group I 
      metabotropic glutamate receptors (I mGluRs), on certain behaviors in rats after 
      short-term hypoxia as a model of experimentally induced amnesia. The effect of 
      (S)-3,5-DHPG administered intracerebroventriculary (icv) at doses of 0.01, 0.1 
      and 1.0 nmol was assessed using behavioral tests: the open field test, the 
      passive avoidance response and the elevated "plus" maze test. (S)-3,5-DHPG did 
      not change the number of crossed fields and rearings and only at a dose of 0.01 
      nmol it increased the number of bar approaches in the open field test. 
      (S)-3,5-DHPG used at all doses improved consolidation, and at doses of 0.01 and 
      1.0 nmol it improved retrieval in the passive avoidance test. (S)-3,5-DHPG did 
      not produce any significant effects in control rats in the elevated "plus" maze 
      test. Hypoxia inhibited locomotor and exploratory activity of rats, significantly 
      impaired consolidation and retrieval processes. We observed tendency to 
      shortening the time spent in open arms and to decrease in the number of entries 
      into open arms in the elevated "plus" maze in rats with underwent hypoxia. In 
      hypoxia-treated groups of rats, (S)-3,5-DHPG inhibited locomotor and exploratory 
      activity in comparison with the control groups administered (S)-3,5-DHPG. Hypoxia 
      significantly inhibited beneficial effects of (S)-3,5-DHPG on consolidation and 
      retrieval in passive avoidance. (S)-3,5-DHPG only at the dose of 1.0 nmol used 
      before hypoxia improved consolidation and at the dose of 0.01 nmol enhanced 
      retrieval in comparison with saline-treated group subjected to hypoxia. 
      (S)-3,5-DHPG only at the dose of 1.0 nmol in hypoxia-treated group shortened the 
      time spent in closed arms and increased the number of entries into closed and 
      open arms in the elevated "plus" maze vs saline-treated group subjected to 
      hypoxia. In rats subjected to hypoxia, (S)-3,5-DHPG, the agonist of I mGluRs, 
      improved consolidation and retrieval and exhibited anxiolytic activity in 
      dose-dependent manner.
FAU - Nadlewska, Agnieszka
AU  - Nadlewska A
AD  - Department of Pharmacology, Medical Academy, Bialystok, Poland.
FAU - Car, Halina
AU  - Car H
FAU - Oksztel, Robert
AU  - Oksztel R
FAU - Wisniewski, Konstanty
AU  - Wisniewski K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Pol J Pharmacol
JT  - Polish journal of pharmacology
JID - 9313882
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (Resorcinols)
RN  - 5YR2N37E6D (3,5-dihydroxyphenylglycine)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Amnesia/complications/physiopathology
MH  - Animals
MH  - Anxiety/drug therapy/*etiology
MH  - Avoidance Learning/drug effects
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Excitatory Amino Acid Agonists/*pharmacology
MH  - Exploratory Behavior/*drug effects
MH  - Glycine/*analogs & derivatives/*pharmacology
MH  - Hypoxia/complications/*physiopathology
MH  - Learning/*drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Motor Activity/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Resorcinols/*pharmacology
MH  - Stereoisomerism
EDAT- 2002/05/22 10:00
MHDA- 2002/11/26 04:00
CRDT- 2002/05/22 10:00
PHST- 2002/05/22 10:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/05/22 10:00 [entrez]
PST - ppublish
SO  - Pol J Pharmacol. 2002 Jan-Feb;54(1):11-8.