PMID- 12020474
OWN - NLM
STAT- MEDLINE
DCOM- 20021001
LR  - 20191106
IS  - 1471-4892 (Print)
IS  - 1471-4892 (Linking)
VI  - 2
IP  - 3
DP  - 2002 Jun
TI  - Diseases of the neuromuscular junction.
PG  - 296-301
AB  - The neuromuscular junction is a prototype synapse and it is also the site of 
      well-characterised autoimmune and hereditary disorders. In the presynaptic 
      terminal, voltage-gated potassium channels and voltage-gated calcium channels are 
      subtly altered in genetic disorders and mutations in the enzyme that synthesises 
      acetylcholine have been demonstrated in a particular form of hereditary 
      myasthenia syndrome. Recent advances have revealed agrin, muscle-specific kinase 
      (MuSK) and rapsyn as important signalling elements in the development and 
      maintainance of the molecular architecture of the postsynaptic membrane. This is 
      proving relevant to seronegative myasthenia gravis, with the discovery of 
      anti-MuSK antibodies, and to a type of congenital myasthenic syndrome, in which 
      acetylcholine receptor deficiency is due to mutations in rapsyn.
FAU - McConville, John
AU  - McConville J
AD  - Neurosciences Group, Weatherall Institute of Molecular Medicine, John Radcliffe 
      Hospital, Oxford, OX3 9DS, UK. jmcconville@hammer.imm.ox.ac.uk
FAU - Vincent, Angela
AU  - Vincent A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Curr Opin Pharmacol
JT  - Current opinion in pharmacology
JID - 100966133
RN  - 0 (Receptors, Presynaptic)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Neuromuscular Diseases/*drug therapy/physiopathology
MH  - *Neuromuscular Junction
MH  - Receptors, Presynaptic/drug effects
MH  - Synapses/drug effects/physiology
MH  - Synaptic Transmission/physiology
RF  - 29
EDAT- 2002/05/22 10:00
MHDA- 2002/10/03 04:00
CRDT- 2002/05/22 10:00
PHST- 2002/05/22 10:00 [pubmed]
PHST- 2002/10/03 04:00 [medline]
PHST- 2002/05/22 10:00 [entrez]
AID - S147148920200156X [pii]
AID - 10.1016/s1471-4892(02)00156-x [doi]
PST - ppublish
SO  - Curr Opin Pharmacol. 2002 Jun;2(3):296-301. doi: 10.1016/s1471-4892(02)00156-x.