PMID- 12020964
OWN - NLM
STAT- MEDLINE
DCOM- 20020708
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 126
IP  - 1-2
DP  - 2002 May
TI  - Microchimerism in autoimmunity and transplantation: potential relevance to 
      multiple sclerosis.
PG  - 126-33
AB  - Microchimerism (MC) is the stable presence of small numbers of non-host cells and 
      appears to be commonly present in parous women. There are several methods of 
      detecting microchimerism and each has advantages for different types of studies, 
      but the risk of contamination and the differing levels of sensitivity lead to 
      difficulties in estimating the proportion of individuals that are microchimeric. 
      Recent observations of an increased frequency of microchimerism in women with 
      scleroderma and Hashimoto's thyroiditis suggest that microchimerism may increase 
      the risk of developing autoimmune disease. Inferences regarding autoimmunity are 
      drawn from the immunological effects of organ and bone-marrow transplantation. 
      Potential research questions regarding microchimerism, human leukocyte antigen 
      (HLA) similarity, and autoimmune diseases in the context of multiple sclerosis 
      (MS) are discussed.
FAU - Willer, Cristen J
AU  - Willer CJ
AD  - Wellcome Trust Centre for Human Genetics, University of Oxford, OX3 7BN, UK.
FAU - Sadovnick, A Dessa
AU  - Sadovnick AD
FAU - Ebers, George C
AU  - Ebers GC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
SB  - IM
MH  - Bone Marrow Transplantation/*immunology
MH  - Female
MH  - Humans
MH  - Multiple Sclerosis/epidemiology/genetics/*immunology
MH  - Pregnancy
MH  - Pregnancy Complications/epidemiology/*immunology
MH  - Prevalence
MH  - Transplantation Chimera/*immunology
RF  - 79
EDAT- 2002/05/22 10:00
MHDA- 2002/07/09 10:01
CRDT- 2002/05/22 10:00
PHST- 2002/05/22 10:00 [pubmed]
PHST- 2002/07/09 10:01 [medline]
PHST- 2002/05/22 10:00 [entrez]
AID - S0165572802000486 [pii]
AID - 10.1016/s0165-5728(02)00048-6 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2002 May;126(1-2):126-33. doi: 10.1016/s0165-5728(02)00048-6.