PMID- 12021163
OWN - NLM
STAT- MEDLINE
DCOM- 20020618
LR  - 20111117
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 143
IP  - 6
DP  - 2002 Jun
TI  - Perspective: the search for genes for type 2 diabetes in the post-genome era.
PG  - 2012-8
AB  - Twin and family studies have demonstrated a strong genetic component to type 2 
      diabetes mellitus (T2DM), but mapping the susceptibility genes that account for 
      this risk has proved difficult. At least seven single gene defects are known to 
      cause T2DM, often with early onset and insulin deficiency, but these causes 
      account for 5% or less of all T2DM. A large number of candidate genes have been 
      evaluated for typical T2DM, but few have been confirmed in multiple studies, and 
      among these, the effect on individual risk is modest. A large number of 
      genome-wide scans have been published in the last few years, and at least four 
      regions show evidence in multiple studies. However, only NIDDM1 has been mapped 
      to a single gene, and that gene (calpain 10) appears to have a major role only in 
      selected populations. Work is ongoing in many laboratories and multiple 
      populations to map additional regions, but T2DM and other complex diseases have 
      proved recalcitrant to current methodology. In addition to the ongoing progress 
      in completing the genome sequence and in developing a comprehensive map of single 
      nucleotide polymorphisms, new statistical models will be needed to incorporate 
      the multiple loci with modest effect and the known environmental interactions 
      that characterize the susceptibility to T2DM.
FAU - Elbein, Steven C
AU  - Elbein SC
AD  - Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA. 
      elbeinstevenc@uams.edu
LA  - eng
GR  - DK-39311/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Insulin)
RN  - EC 2.7.10.1 (Receptor, Insulin)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Humans
MH  - Insulin/genetics
MH  - *Molecular Biology
MH  - Receptor, Insulin/genetics
RF  - 102
EDAT- 2002/05/22 10:00
MHDA- 2002/06/19 10:01
CRDT- 2002/05/22 10:00
PHST- 2002/05/22 10:00 [pubmed]
PHST- 2002/06/19 10:01 [medline]
PHST- 2002/05/22 10:00 [entrez]
AID - 10.1210/endo.143.6.8831 [doi]
PST - ppublish
SO  - Endocrinology. 2002 Jun;143(6):2012-8. doi: 10.1210/endo.143.6.8831.